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中药功效概念网络构建及其应用

ISSN号：1664-3849
期刊名称：世界科学技术-中医药现代化
时间：2013
页码：638-642
分类：R285[医药卫生—中药学;医药卫生—中医学]
作者机构：[1]北京中医药大学中药信息工程研究中心,北京100102
相关基金：国家自然科学基金委面上项目（30973946）：基于三阴三阳系统的药性组合模式及其作用机理研究,负责人：王耘,国家自然科学基金委面上项目（81173568）：基于三阴三阳的经方药对语法系统及其作用机制研究,负责人：王耘; 科学技术部国家科技支撑计划项目（2008BAI51B01）：中药有效成分群辨识技术研究,负责人：张宏桂
相关项目：基于三阴三阳的经方药对语法系统及其作用机制研究

关键词：中药功效, 概念网络, 配伍, Traditional Chinese medicine efficacy, concept network, compatibility

中文摘要：

目的：建立中药功效概念网络,揭示中药功效间的联系,明确功效概念网络的应用途径。方法：通过整理2010年版《中华人民共和国药典》（一部）记载的中药功效,对中药功效概念间的关联关系进行系统分析,构建功效概念网络,并从中抽提特定功效的子网络,利用网络聚类算法发现连锁出现的功效群。结果：构建包含422个功效概念的中药功效概念网络,发现经常连锁出现的21个功效群,并以活血功效为例,构建了活血功效的子网络,分析子网络在药物配伍中的应用方法。结论：中药功效概念网络是中医基础理论和临床用药经验的集中体现,能够系统揭示中药功效之间的联系,有利于指导中药的合理应用配伍,为疾病的治疗提供新的思路。

英文摘要：

This study was aimed to establish Chinese medicine efficacy concept network in order to reveal the inner relation between traditional Chinese medicine（TCM） and efficacy as well as to suggest the application way of efficacy concept network.Through the collation of medicine efficacy recorded in the Pharmacopoeia of the People＇s Republic of China（2010 Edition,Volume I）,the correlation relationship between TCM efficacy concept was systematically analyzed,and the efficacy concept network was constructed in order to extract specific effica cy sub-network based on efficacy concept network and then to discover the efficacy groups by utilizing the net work clustering algorithm.In the Chinese medicine efficacy concept network,422 efficacy concepts were con structed and 21 tightly efficacy groups were discovered.Using the efficacy of promoting blood circulation as an example,the application of sub-networks was discussed.Chinese medicine efficacy concept network can be used to reflect the basic theory and clinical experiences in Chinese medicine,to systematically reveal the relationship between TCM efficacy concepts,which can be beneficial to guide the reasonable application of Chinese medicine in disease treatment.

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