为了评估光电容积脉搏波法在人体血液主要成分检测方面的精度水平,基于朗伯比尔定律及简化的光电容积脉搏波法测量模型,给出了物质成分测量的极限分辨浓度公式。对公式中的三个要素,即人体测量时的光强信噪比、光程、被测物质的摩尔消光系数进行了评估,获得了理论上光电脉搏波法对血红蛋白、白蛋白、血糖的极限分辨浓度。评估结果表明,光电容积脉搏波法可以测量的血红蛋白、白蛋白和血糖的极限分辨浓度水平分别约为100mg/dL,5000mg/dL以及10 000mg/dL。将该评价结果与现阶段临床需要的检测精度进行对比,可知光电容积脉搏波法能够满足需求,有望实现对血红蛋白的无创检测。
To evaluate the precision level of Photolepthysmography(PPG)in detection of the main components of human blood,the formula for the limit resolution concentration of material components measurement was given based on the Lambert-Beer's Law and simplified measurement model of PPG.Through the evaluation of three elements-Signal-to-Noise Ratio(SNR)of light intensity,optical path and the molar extinction coefficient of the blood components during human measurements,the theoretical limit resolution concentrations of the pulse oximeter signal method for hemoglobin,albumin and blood glucose were obtained.The evaluation result shows that the limit resolution concentration levels of hemoglobin,albumin and blood glucose which can be measured through PPG are respectively100mg/dL,5000mg/dL and 10 000mg/dL.The comparison of the evaluation result with the detection precision needed on clinic at the present stage indicates that the PPG can meet the demands for the non-invasive detection of hemoglobin.