中文摘要：

长链非编码RNA（long non-coding RNA,lncRNA）是细胞中一类转录本长度超过200个核苷酸的非编码RNA分子,本身并不编码蛋白或很少有编码蛋白质功能,在哺乳动物基因组普遍被转录。起初认为它是转录过程中的副产物,不具有生物学功能。随着研究的深入,新的lncRNA不断被发现,越来越多的证据显示lncRNA具有复杂的生物学功能,并与人类疾病的发生关系密切。

英文摘要：

Long noncoding RNAs（lncRNAs） are defined as transcripts longer than 200 nt with little or no protein-coding capacity that are generally transcribed in the mammalian genome.Initially,they are considered to be a byproduct in the transcription process without biological function.As investigations have progressed,however,new lncRNAs have been constantly found,and more and more evidence shows that lncRNAs possess complex biological functions and are closely related to human diseases.