细胞休眠是生物界普遍存在的一种现象,也是恶性肿瘤细胞生物学特征之一。肿瘤休眠细胞的存在,是导致其复发和远处转移的主要原因,其发生机制可能与休眠相关基因激活、肿瘤血管生成、肿瘤免疫逃逸、癌基因与抑癌基因、信号转导等因素相关。
Cell dormancy is not only a widespread phenomenon in living nature but also a biologic character of malignant tumor cells. Tumor dormancy cell is the primary cause of tumor relapse and metastasis. The mechanism is correlated with activation of tumor dormancy related gene ( Restin), tumor angiogenesis, tumor immune escape, oncogene and antioncogene, signal conduction, etc.