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Jumonji家族的无毛蛋白与毛发缺失
  • ISSN号：1000-1336
  • 期刊名称：《生命的化学》
  • 时间：0
  • 分类：Q75[生物学—分子生物学]
  • 作者机构：[1]中国医学科学院基础医学研究所, [2]北京协和医学院基础学院医学分子生物学国家重点实验室,北京100005
  • 相关基金：国家自然科学基金（30721063）资助
作者： 米洋[1], 张业[2]
关键词： hairless基因, 毛发周期, JmjC结构域, hairless gene （Hr）, hair cycle, JmjC domain
中文摘要：

Jumonji家族中的一个成员hairless基因（Hr）在小鼠和人体内的突变可以导致显著的毛发生长障碍。HR影响的生理过程是出生后的毛发周期（haircycle）,而非胚胎期的毛囊形态发生（hairmorphgenesis）。HR与维生素D受体（vitaminDreceptor,VDR）在体外可以直接相互作用,并对基因转录有抑制作用,提示HR是核受体的转录辅抑制因子（corepressor）,转录抑制机制可能是通过组蛋白去乙酰基酶（histonedeacetylase,HDAC）等实现。HR的蛋白质结构和亚细胞定位提示其可能通过其他机制改变染色质的状态从而实现对靶基因的表达调控。

英文摘要：

The hairless protein （HR）, a member of the jumonji family, has long been suspected to regulate a stem cell-mediated process, hair cycling. Mutations in the Hr gene cause hair loss both in mice and human beings. The HR protein which interacts with vitamin D receptor （VDR） and histone deacetylase （HDAC） family members is a nuclear receptor corepressor that functions in hair cycling by regulating gene expression. However, it is still unclear whether the JmjC domain of HR and its specific subcelluar localization play roles in chromatin regulation.

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重大疾病相关基因的表达调控与发病机制的研究
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期刊信息
  • 《生命的化学》
  • 中国科技核心期刊
  • 主管单位:中国科学技术协会
  • 主办单位:中国生物化学与分子生物学会
  • 主编：阮康成
  • 地址：上海岳阳路319号
  • 邮编：200031
  • 邮箱：smhx@sibs.ac.cn
  • 电话：021-54921091
  • 国际标准刊号：ISSN：1000-1336
  • 国内统一刊号：ISSN：31-1384/Q
  • 邮发代号:4-315
  • 获奖情况:
  • 国内外数据库收录:
  • 被引量:8895