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中文摘要：
目的探讨单胺氧化酶A(MAOA)基因启动子可变数目重复序列(VNTR)多态性与重性抑郁症易感性的关系。方法采用PCR技术检测512例重性抑郁症患者与566名对照VNTR重复序列分布频率是否具有差异,并使用汉密顿焦虑量表对重性抑郁症患者进行评估。结果男性及女性重性抑郁症患者MAOA VNTR等位基因频率与对照相比差异无显著性;基因型分析显示,女性重性抑郁症患者与对照相比,L等位基因携带者频率显著升高(P=0.002),男性患者与对照相比分布频率差异无显著性(P=0.17)。表型分析显示,女性患者携带L等位基因的基因型(P=0.0056)与汉密顿焦虑量表"害怕"表型的发生显著相关。结论MAOA VNTR多态性可能与女性中国北方汉族人群重性抑郁症发病相关,且可提高抑郁症表型的发生。
英文摘要：
Objective To explore the association between monoamine oxidase A(MAOA) variable number tandem repeat(VNTR) polymorphism and major depression in Chinese Han population.Methods Polymerase chain reaction was used to genotype MAOA VNTR polymorphism.A total of 512 major depression patients and 566 normal controls were recruited in our study.These patients were also assessed using the 14-item Hamilton anxiety scale.Results The allele frequency of MAOA VNTR was not significantly different between the male/female m...
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