中文摘要：

目的研究liguzinediol在大鼠体内的药动学特征及其绝对生物利用度。方法36只SD大鼠，♀♂各半，灌胃或尾静脉给予不同剂量liguzinediol，于不同时间点分取血浆，采用UPLC方法对血浆中liguzinediol的浓度进行测定，运用DAS2．0药动学软件计算药动学参数及绝对生物利用度。结果灌胃给予liguzinediol高、中、低剂量（50、20、10mg·kg-1）与静脉给予liguzinediol高、中、低剂量（20、10、5mg·kg-1）的AUC0-∞和给药剂量呈线性关系，在大鼠体内的口服绝对生物利用度大于90％。结论Liguzinediol符合线性药动学，口服绝对生物利用度高，半衰期较短。

英文摘要：

AIM To study the pharmacokinetics characteristics of liguzinediol and its absolute bioavail- ability in rat. METHODS The plasma from 36 SD rats （half male and half female） with intragastric and intravenous administration were collected in different time point. The plasma concentration of liguzinediol was determined by UPLC. The pharmacokinetic parameters and absolute bioavailability were calculated by DAS 2.0 software. RESULTS The AUC0-∞ showed linear-relation after intragastric （50, 20, 10 mg-kg-1） and intravenous （20, 10, 5 mg-kg-1） administration. And the absolute bioavailability was higher than 90%. CONCLUSION capacity, short The pharmacokinetic study shows that liguzinediol is characterized with good oral absorption eliminate half- life, and linear pharmacokinetics, suggesting that its pharmacokinetic performances are appropriate and merit further development