中文摘要：

目的：探讨抑郁症患者酪氨酸磷酸酶受体R亚型（protein tyrosine phosphatase receptor type R, PTPRR）基因rs1513105多态性对静息态脑功能的影响。方法对54例抑郁症患者（病例组）及43名性别、年龄、受教育年限匹配的健康志愿者（对照组）进行静息态磁共振成像扫描和PTPRR基因分型，探讨疾病状态、基因型的主效应和二者的交互作用。结果方差分析结果显示：（1）疾病状态为主效应：与对照组相比，病例组左颞上回（t=4.2082）、右缘上回（t=3.0271）、左顶上小叶（t=3.2122）局部一致性（regional homogeneity, ReHo）值升高（均P〈0.05）；（2）基因多态性为主效应：与TT基因型组相比，G等位基因携带组左顶下小叶（t=3.1290）、左中央后回（t=3.2633）ReHo值升高（均P〈0.05），右尾状核（t=-3.4434）、右岛盖部额下回（t=-3.4445）、右侧小脑（t=-3.0793）ReHo值下降（均P〈0.05）；（3）疾病状态与基因多态性的交互作用：与对照组相比，病例组G等位基因携带组较TT基因型组右颞下回（t=3.5602）、右三角部额下回（t=3.2961）ReHo值升高（P〈0.05），左颞上回（t=-4.3543）、左楔前叶（t=-4.0267）、左额上回（t=-3.6560）、左枕下回（t=-3.8054）、右缘上回（t=-3.4332）ReHo值下降（P〈0.05）。Pearson相关分析结果显示，病例组左枕下回ReHo值与认知障碍因子分（r=0.323, P=0.017）和睡眠障碍因子分（r=0.318, P=0.019）呈正相关，右缘上回ReHo值与认知障碍因子分（r=0.273, P=0.046）呈正相关。结论 PTPRR-rs1513105基因多态性与抑郁症的交互作用可能导致部分抑郁相关脑区静息态脑功能变化，并可能和抑郁症的发病机制有关。

英文摘要：

Objective To explore the influence of a polymorphism of protein tyrosine phosphatase receptor type R （PTPRR） gene rs1513105 on abnormal brain activities in resting-state patients with major depressive disorder （MDD） using the gene-imaging technology. Methods 54 MDD and 43 gender-, age-, and education-matched controls received fMRI scans and genotyping to identify the main effect of disease status, genotypes and their interaction in MDD. Results The results of 2 × 2 ANOVA showed increased ReHo in left superior temporal gyrus （t= 4.208 2）, right supramarginal gyrus（t= 3.027 1）, left superior parietal gyrus （t=3.212 2） were in patients than controls. The carriers with TT genotype showed increased ReHo in left inferior parietal gyrus （t=3.129 0）, left postcentral gyrus （t=3.263 3） and reduced ReHo in right caudate nucleus （t=-3.443 4）, right inferior frontal gyrus, opercular part （t=-3.444 5）, right cerebelum （t=-3.079 3） than G allele carriers（P〈0.05）. The patients showed increased ReHo in right inferior temporal gyrus （t=3.560 2）, right inferior frontal gyrus, triangular part （t=3.296 1） and reduced ReHo in left superior＆nbsp;temporal gyrus （t=-4.354 3）, left precuneus（t=-4.026 7）, left superior frontal gyrus（t=-3.656 0）,left inferior occipital gyrus （t=-3.805 4）, right supramarginal gyrus （t=-3.433 2） than controls, comparing G allele carriers with TT genotype carriers. Reduced ReHo in left inferior occipital gyrus was positively correlated with cognitive （r=0.323, P= 0.017） and sleep disturbance （r=0.318, P= 0.019）, Reduced ReHo in right supramarginal gyrus was positively correlated with cognitive disturbance （r=0.273, P= 0.046）. Conclusion The interaction between PTPRR gene polymorphism and MDD may contribute to the change of resting-state function of some depression-related brain region, and might be involved in the pathogenesis of MDD.