中文摘要：

目的检测表皮生长因子受体Ⅲ型突变体（EGFRvⅢ）在肾透明细胞癌组织中的表达，探讨其与肾透明细胞癌发生、发展的关系。方珐采用免疫组织化学染色和图像分析法检测80例肾透明细胞癌和24例正常肾组织中EGFRvⅢ的表达水平，进行统计学分析、比较。培杲肾透明细胞癌组织和正常肾组织EGFRvⅢ的表达阳性率分别为46％、8％。通过半定量分析，二者EGFRvⅢ平均灰度值分别为148．49±13．05和155．65±14．86，其差异具有统计学意义（t=2．13，P=0．04）；男、女患者EGFRvⅢ的平均灰度值分别为149．01±13．70和147．40±11．76，二者无显著性差异（t=0．54，P=0．59）；EGFRvⅢ表达与年龄无显著相关性（r=0．01，P=0．92）。培论EGFRvⅢ在肾透明细胞癌组织中存在高表达，与肾透明细胞癌的发生、发展有一定关系。

英文摘要：

Objective To detect expression of epidermal growth factor receptor variant Ⅲ （EGFRvⅢ） in human suprarenal epithelioma to explore its relation with the genesis and development of suprarenal epithelioma. Methods Immunohistochemistry and pathologic image analysis were used to semiquantitatively detect the expression of EGFRv Ⅲ protein in eighty human suprarenal epithelioma tissues and twenty-four normal renal tissues. Results Positive expression rate of EGFRvⅢ was 46% in human suprarenal epithelioma tissues and 8% in normal renal tissues. Their average gray scale values were 148.49 ± 13.05 and 155.65 ± 14.86, respectively, which showed a significant difference （t =2.13, P=0.04）. There was no obvious difference between males and females （149.01 ± 13.70 and 147.40 ± 11.76, t = 0.54, P = 0.59）. No significant association was observed between EGFRvⅢ expression and age （r =0.01, P = 0.92）. Conclusion Many human suprarenal epithelioma tissues express EGFRvⅢ . EGFRvⅢ may play certain role in the genesis and development of human suprarenal epithelioma.