中文摘要：

目的：检测血红素加氧酶-1（hemeoxygenase，HO-1）与多药耐药相关蛋白2（muhidrug resistanceassociated protein2，MRP2）在原发性胆囊癌组织中的表达，探讨其与胆囊癌发生、发展的关系。方法：采用免疫组化SP法检测67例原发性胆囊癌患者中HO-1和MRP2的表达水平。结果：原发胆囊癌组织HO-1和MRP2表达的总阳性率分别为73．1％、77．6％。其中腺癌的阳性率为76．7％和80％。依据病理分级，HO-1和MRP2表达水平由高到低分别为Ⅲ级〉Ⅱ级〉Ⅰ级，且具有统计学差异（P=0．028，P=0．023）；HO-1、MRP2的阳性表达与年龄、性别等临床特征无相关性；HO-1和MRP2表达之间具有良好的相关性（r=0．324，P=0．005）。结论：HO-1和MRP2在原发性胆囊癌组织高表达，对胆囊癌的发生、发展提供有利条件，二者之间表达具有良好的相关性。

英文摘要：

Objective：To detect expression of heme oxygenase （ HO - 1 ） and multidrug resistance - associated protein 2 （ MRP2 ）, and investigate its significance in primary gallbladder carcinoma. Methods ： Sixty - seven patients with primary gallbladder carcinoma entered this study. Immunohistochemistry （SP assay） and image analysis was used to semiquantitatively detect the expression of HO - 1 and MRP2 protein. Results ： Positive expression rates of HO - 1 and MRP2 were 73.1% and 77.6% respectively in primary gallbladder carcinoma. The expression of HO -1 and MRP2 had a significantly correlation with pathological grading （P =0. 028 ,P = 0. 023 ）. HO -1 and MRP2 expression level showed no statistical associated with sex and age. Conclusion： Both of HO - 1 and MRP2 overexpressed in primary gallbladder carcinoma and may play certain role in development of primary gallbladder carcinoma.