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中文摘要：
将分子印迹技术与整体柱技术相结合，在色谱柱中原位聚合所制备的分子印迹整体柱不仅具有分子印迹聚合物（Molecularly imprinted polymer，MIP）优异的分子识别性能，而且具有整体柱（Monolith）的高效、高通量及低背压等特点，同时也克服了常规本体聚合制备MIP的分离效率低、研磨筛分费时费力、粒子不规则及印迹位点在研磨过程中受损等缺点，
英文摘要：
A monolithic molecularly imprinted polymer （monolithic MIP） for trimethoprim （TMP） was prepared by in situ polymerization method as the HPLC stationary, phase. Methacrylic acid（MAA） and ethylene glycol dimethacrylate（EDMA） were used as functional monomer and cross-linker, respectively. The obtained MIP monoliths were characterized by high performance liquid chromatography and scanning electron microscope. The SEM analysis result clearly shows that many macropores and flow-through pores were embedded in the network skeleton of the TMP-imprinted monolith, which allowed the mobile phase to flow through the monolithic MIPs with a very low flow resistance. When the flow rate was high to 9.0 mL/min, the backpressure was only 11.1 MPa. Moreover, the imprinting factor was up to 10.3, which demonstrates that the obtained monolithic MIP showed a strong affinity and selectivity to the template molecule.
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