中文摘要：

米尔贝霉素（Milbemycins）是一系列在结构上非常类似的十六元环大环内酯类抗生素，可由几种链霉菌产生，具有强烈的杀虫和杀螨等生物学活性。自1967年发现首个米尔贝霉素类化合物以来，大量结构类似的其他化合物被报道。国际上已有多个米尔贝霉素类药品实现了商业化，被广泛地用作兽医药物或作物保护农药。主要综述了米尔贝霉素的产生菌，理化性质、生物学活性及应用。

英文摘要：

Milbemycins, a series of 16-membered macrocyclic lactones, can be produced by several species of Streptomyces. They display strong insecticidal, acaricidal and other biological activities. Since the first milbemycin compound was found in 1967, a lot of its analogues have been reported. Several drugs, widely used as veterinary drugs or pesticides for crop production, have been developed and commercialized from milbemycins. The research advances in the producing microorganisms, physico-chemical properties, biological activities and applications of milbemycins are mainly reviewed.