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中文摘要：
阻塞性睡眠呼吸暂停低通气综合征（OSAHS）是一种发病率高．具有潜在危险的常见病．定量描述呼吸气流流场的分布情况是阻塞平面正确定位的可靠依据．基于OSAHS患者与正常人上呼吸道螺旋CT影像数据及weibel模型A的气管-支气管模型，建立了精确量化的上呼吸道生物力学模型．将患者与正常人的数值模拟结果进行比较，得出患者上呼吸道气流速度、压力和壁面剪切应力的分布以及数值均明显异于正常人情况．模拟结果的对比研究有助于探讨人体呼吸道解剖结构的异常对气流分布的影响，对临床上正确诊断与有效治疗该病、深入研究该病与各系统并发症之间的关系都具指导意义．
英文摘要：
Obstructive sleep apnea hypopnea syndrome （OSAHS） is a highly prevalent and potentially risky disease. Correct location of obstructive sites depends on quantitative description of airway flow field distribution. Based on CT images of patients with OSAHS and normal adults, and Weibel trachea-bronchi model A, quantificational and accurate biomechanics models of upper airway are built. By comparison of numerical results, it is obvious that patients with OSAHS are different from normal adults on the flow field patterns and values of velocity, pressure and shear stress. The comparative study is beneficial to evaluating the influence of abnormal airway anatomy on the flow distribution, diagnosing correctly and curing effectively the OSAHS in clinic and investigating the relationship between the OSAHS and complications.
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