中文摘要：

目的研究高甘油三酯血症性胰腺炎（HTGP）与其他病因引起的急性胰腺炎（AP）在病情严重程度和临床预后上的差异，并分析HTGP发病24h的血清甘油三酯（TG）水平与病情严重程度的相关性。方法从南昌大学第一附属医院的AP数据库中选取2005年1月至2013年12月入院、年龄≥18岁且≤85岁并排除妊娠或哺乳期妇女的患者，按最新指南进行病因分类和严重程度分级，比较HTGP患者（HTGP组）和其他病因AP患者（非HTGP组）的病情严重程度和临床预后；选取发病24h内入院的HTGP患者，比较轻症、中度重症和重症HTGP患者发病24h血清TG水平的差异，分析血清TG水平与病情严重程度的相关性。结果共纳入3558例AP患者，其中HTGP组623例（17．5％），非HTGP组2935例（82．5％）。HTGP组与非HTGP组的胰腺坏死发生率为28．3％比18．1％、感染性胰腺坏死发生率为6．1％比3．7％、器官衰竭发生率为35．8％比29．1％、持续性器官衰竭发生率为24．4％比16．5％，差异均有统计学意义（均P〈0．01）。HTGP组的病死率、中位重症监护天数也高于非HTGP组（均P〈0．05）。发病24h内入院的291例HTGP患者中，轻症、中度重症和重症患者发病24h血清TG水平分别为（9．38±9．00）、（11．90±9．02）和（16．47±11．75）mmol／L，差异有统计学意义（P〈0．01）；Spearman相关分析显示发病24h的TG水平与病情严重程度呈正相关（r=0．26，P〈0．01）。结论HTGP患者的病情严重程度比其他病因AP更重，临床预后更差。HTGP患者发病24h的血清TG水平与病情严重程度呈正相关。

英文摘要：

Objective To investigate the difference in severity and clinical outcomes between hypertriglyceridemic pancreatitis （HTGP） and acute pancreatitis （AP） of other causes, and to analyze the correlation between the serum triglyceride （TG） level 〈 24 h after onset and the disease severity. Methods Patients were selected from the AP database of the First Affiliated Hospital of Nanchang University, who were admitted between January 2005 and December 2013, aged i〉 18 and ~〈85 years, excluding pregnant or lactating women. Severity and etiology of AP were classified according to the latest relevant guidelines. The severity and clinical outcomes of HTGP patients （ HTGP group） were compared with those of patients with AP of other causes （ non-HTGP group）. Among the HTGP patients, those admitted within 24 hours of onset were selected for comparison of serum TG levels on the first day of hospitalization day among patients with mild, moderate, and severe HTGP, and the correlation between the serum TG level and the severity was analyzed. Results Altogether 3 558 AP patients were selected, of which 623 （ 17.5% ） were HTGP, and 2 935 （82. 5% ）were non-HTGP patients. Compared with the non-HTGP group, the HTGP group had higher incidence of pancreatic necrosis （28.3% vs 18. 1% ） , infected pancreatic necrosis （6. 1% vs 3.7% ） , organ failure（35.8% vs 29. 1% ）, and persistent organ failure（24. 4% vs 16. 5% ）, with all the differences being statistically significant （all P 〈 0. 01 ）. The mortality and average stay in intensive care unit were also higher in the HTGP group than in the non-HTGP group （all P 〈0. 05）. There were 291 patients with HTGP who were admitted to hospital within 24 hours of onset. The serum TG levels 〈 24 h after onset were （9. 38 ± 9.00） mmol/L, （ 11.90 ± 9. 02） retool/L, and （ 16. 47 ± 11.75 ） mmol/L in patients with mild, moderate, and severe HTGP, respectively （P 〈 0. 01 ）. Spearman＇s correlation analysis showed a positive co