中文摘要：

通过建立以致病性大肠杆菌感染小鼠为模型,研究氧化修饰前后嗜酸乳杆菌肽聚糖（peptidoglycan,PG）对小鼠肠道上皮细胞病理形态影响,及对感染大肠杆菌肠黏膜分泌s Ig A、血清干扰素-γ（interferon-γ,IFN-γ）和肿瘤坏死因子-α（tumor necrosis factor-α,TNF-α）的影响,发现灌胃PG后能够促进小肠黏膜分泌s Ig A,降低IFN-γ及TNF-α的表达,且选择性氧化修饰PG比未修饰PG具有优势。可见,嗜酸乳杆菌在肠道免疫方面,可以通过其功能性PG提高对小肠黏膜的免疫调控作用。

英文摘要：

As an important immune system,mucosal immune system is the first line to protect the mucous membranes against colonization and invasion by potentially dangerous microbes that may be encountered.In this study,the immunoregulatory activity of Lactobacillus acidophilus peptidoglycan（PG） was investigated on pathogenic Escherichia coli（E.coli）-induced mouse model.Compared with PG,the oxidative modification of PG had a significant effect on the secretion of s Ig A,reduced the expression of interferon-γ（IFN-γ） and tumor necrosis factor-α（TNF-α） in the intestinal mucosa.PG derived from Lactobacillus acidophilus had the capability of enhancing immune regulation of intestinal mucosa.