中文摘要：

目的：观察碘化N-正丁基氟哌啶醇（F2）对大鼠心肌组织缺血再灌注（I/R）损伤病理改变及早期生长反应蛋白-1（Egr-1）表达变化的影响。方法：制作大鼠I／R损伤模型。常规病理染色技术观察心肌组织形态学变化。免疫组织化学法测定缺血心肌组织Egr-1阳性表达的细胞数。结果：I／R造成大鼠心肌组织病理损伤，尤以炎症反应为重；I／R诱导心肌组织Egr-1表达上调。缺血前给予F2则能减轻I／R所致心肌组织内的各种病理反应，抑制心肌组织内Egr-1的过表达。结论：F2对大鼠I／R心肌组织损伤具有保护作用，这可能与其抑制Egr1-过表达有关。

英文摘要：

Objective： To investigate the relationship between the protective effects of N-n-butyl haloperidol iodide （F2） on myocardial ischemia/reperfusion（fiR） injury and the expression of Egr-1. Methods： The rat myocardial I/R models were established. The pathological changes of myocardial tissue were detected by hematoxylin-eosin staining. The early growth response-1 （Egr-1）immunopositive ceils were counted by immunohistochemistry. Results： I/R caused pathological injury, especially inflammatory response and induced strong expression of Egr-1 in myocardial tissue. F2 significantly attenuated the myocardial injury and inhibited the overexpression of Egr-1 after I/R. Conclusion： F2 can protect myocardium from I/R injury, which might be related to the inhibition of Egr-1 overexpression.