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中文摘要：
志贺氏菌也称痢疾杆菌，属于革兰氏阴性细胞内致病菌，主要侵害结肠，引发炎症并形成溃疡，可引起频繁的粘液性血性腹泻，儿童和幼龄动物有较高的感染率和死亡率。目前志贺氏菌病的临床治疗很困难，对志贺氏菌病发病机制的研究可为临床治疗提供理论依据，本文从志贺氏菌的胞内入侵机制、分子机制和免疫机制等方面概述志贺氏菌病发病机制的研究进展。
英文摘要：
Shigella is also called dysentery bacillus,belongs to gram-negative pathogenic bacteria,which can cause inflammation and ulcers in colon.Besides,Shigella also can cause frequent bloody diarrhea,children and young animals have higher infection rate and mortality.At present it is very difficult to treat the shigellosis.But the pathogenesis of shigellosis could provide a theoretical basis for clinical treatment.The progresses in research of pathogenesis of shigellosis are reviewed in this paper.
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