中文摘要：

ITCH又称AIP4（atrophin 1相互作用蛋白4）,最初是在研究小鼠表皮颜色时被发现的。ITCH是一个单体蛋白,属于同源的HECT类型的泛素连接酶E3家族,参与体内多种蛋白质的泛素化降解过程;参与免疫反应;参与多种细胞过程,包括细胞循环、增殖和凋亡;在肿瘤的形成过程中发挥重要的作用。现就ITCH的功能及其与疾病的关系研究进展予以综述。

英文摘要：

ITCH/AIP4（atrophin 1 interacting protein 4,referred to as AIP4）was originally described from studies on mouse epidermis color.ITCH is a monomeric protein,which belongs to the homologous to E6-AP carboxy terminus（HECT）-type family of E3,involved in a variety of proteins ubiquitination degradation process in vivo,involved in immune response,participated in a variety of cellular processes,including cell cycle,proliferation and apoptosis;it plays a very important role in the process of tumor formation.Here is to make a review on the ITCH function and its relationship with diseases.