中文摘要：

睾丸中的胶质细胞源神经营养因子由支持细胞、管周细胞、精母细胞和球形精子合成和分泌,是调节精原干细胞自我更新和分化的关键因子;GDNF通过与SSCs膜上受体GFRα1结合形成GDNF-GFRα1复合物,再结合并活化RET,最后激活MAPK、SFK和PI3K-AKT信号通路并达到调控SSCs自我更新和分化的目的。

英文摘要：

Glial cell line-derived neurophic factor（ GDNF） is secreted by sertoli cells,peritubular myoid cells,spermatocytes and roud spermatids in testes,is a critical component during self-renwal of spermatogonial stem cells（ SSCs） self-renewal. GDNF binds to GFRα1,expressed on the surface of SSCs,to form a heterodimer complex.As a consequence,this complex via activation of RET,triggers MAPK,SFK and PI3K-ATK signaling pathway to regulate SSCs self-renewal and differentiation.