欢迎您！东篱公司
退出
-
申报数据库
-
立项数据库
-
成果数据库
-
项目获奖数据库
中文摘要：
以4-乙烯基苯硼酸（VPBA）为功能单体，季戊四醇三丙烯酸酯（PETA）为交联剂，乙二醇和二甘醇为二元致孔剂，通过热引发自由基聚合反应，在毛细管内原位聚合制备得到一种poly（VPBA-co-PETA）毛细管整体柱。所制备的整体柱具有典型的硼酸亲和特性，可以特异性地捕获含有顺二羟基的化合物。在前期试验的基础上，将其用于两种中草药——蒲公英和刺果卫矛中含顺二羟基的小分子活性物质的富集。这两种中药提取物直接用高效液相色谱进行测检时，其活性成分绿原酸等因含量态度而使检测困难或无法检测；经过硼酸亲和整体柱富集后收集洗脱液进行测检，色谱峰响应则明显提高。该结果表明所制备的poly（VPBA-co-PETA）整体柱可以作为富集中药提取物中含顺二羟基活性物质的有效手段。
英文摘要：
A novel poly（4-vinylphenylboronic acid （ VPBA）-co-pentaerythritol triacrylate （ PE- TA） ） monolithic column was prepared by thermal-initiated copolymerization of VPBA and PE- TA in a binary porogen system comprising diethylene glycol and ethylene glycol. The fabricated monolithic column demonstrated good boronate affinity property, which can specifically cap- ture cis-diols containing compounds. We developed such a monolithic column and applied it to enrich active components in Herba Taraxaci and Euonymus acanthocarpus. The extracts of the two traditional Chinese medicines were separated and enriched on μHPLC by the prepared monolith, and the fractions were collected and examined by HPLC. The results showed that the responses of the corresponding peaks were greatly improved, indicating that the poly （VPBA-co- PETA） monolithic column can be efficiently used to enrich active components in traditional Chinese medicines containing cis-diols group.
同期刊论文项目
同项目期刊论文
Fast quantification of endogenous carbohydrates in plasma using hydrophilic interaction liquid chrom
A platform for fast screening potential anti-breast cancer compounds in traditional Chinese medicine
Urinary metabolomic study of non-small cell lung carcinoma based on ultra high performance liquid ch
Preparation of Zirconia Silica Core Shell Microspheres and Its Application for Highly Specific Phosp
Selectivity Tuning in Pressurized Capillary Electrochromatography with a Zwitterionic Monolithic Col
Development of fully automated quantitative capillary electrophoresis with high accuracy and repeata
Preparation and evaluation of monodispersed, submicron, non-porous silica particles functionalized w
Solid-phase extraction approach for phospholipids profiling by titania-coated silica microspheres pr
Comprehensive ultra-performance liquid chromatographic separation and mass spectrometric analysis of
Study on the pharmacokinetics and metabolism of costunolide and dehydrocostus lactone in rats by HPL
Preparation, Characterization and Applications of Poly( 4-vinylphenylboronic-co-pentaerythritol tria
Development of evaporative light scattering detector for capillary electrochromatography and capilla
Polyethyleneimine-grafted boronate affinity materials for selective enrichment of cis-diol-containin
Development and Evaluation of Quantitative Capillary Electrophoresis with a 4-nL Internal Loop Injec
Recent advances on capillary columns, detectors, and two-dimensional separations in capillary electr
期刊信息
位置：