中文摘要：

目的运用传递函数法通过外周肱动脉脉搏来估测中心动脉压力波,并联合心音、心电信号辅助估测中心动脉的血流动力学重要参数。方法中心动脉压力波对分析人体心血管系统功能至关重要,然而它却不能直接无创测量。本文首先针对每个个体建立了从肱动脉到中心动脉的个体化传递函数模型,然后将个体模型整合成为通用的传递函数模型。结果通过临床实验评估,发现运用传递函数法能很好的重建中心动脉压力波形。结论该方法提供了一种实现无创检测中心动脉参数的简单手段。

英文摘要：

Objective To adopt the transfer function method to estimate the central aortic pressure wave through peripheral brachial pulse wave, and to estimate the main parameters of the hemo-dynamics of the central artery in combination with the heart sound and ECG signals. Methods Central aortic pressure wave is essential to the analysis of the function of cardiovascular systems, but it cannot be measured noninvasively. In this paper, the Individualized Transfer Function（ITF） model of the vascular system from the brachial artery to the central artery is established for each individual. Then the individual models are integrated into a Generalized Transfer Function（GTF） model. Results By means of clinical laboratory evaluation and the comparison between estimated central aortic waveform and the invasively measured central artery waveforms, it is found that the use of the transfer function method can well reconstruct the central artery pressure waveform, and its parameters are estimated accurately. Conclusion This paper provides an efficient and feasible method to obtain the parameters of central aortic pulse wave noninvasively.