中文摘要：

目的观察促红细胞生成素（EPO）在心肺复苏术后的表达情况及其对复苏后心功能不全的干预作用。方法随机将72只SD大鼠分为假手术组（S组）、常规复苏组（C组）及促红细胞生成素组（EPO组）三组,每组又分为0h、2h、4h、6h四个亚组,每个亚组6只。假手术组做动脉穿刺、气管切开、普通上氧（3L/min）,常规复苏组及EPO组（复苏前给EPO 5 000U/kg）做动静脉穿刺、气管切开、有创机械通气及心肺复苏。假手术组、常规复苏组各观察时点采血测EPO水平;并监测各组间0h、2h、4h、6h的心率（HR）、平均动脉压（MAP）、左室收缩峰压（LVSP）、左室舒张末期压力（LVEDP）、左室最大上升与下降速率（±LVdP/dtmax）。结果假手术组各时间点EPO值随有创操作时间增加而逐渐增加,与术前比较差异有统计学意义（P〈0.01）,血液动力学指标及心功能指标较术前组稍增高,但差异无统计学差异（P〉0.05）。常规复苏组血清EPO值先升高后下降,复苏后2h、4h亚组与术前组相比较差异有统计学意义（P〈0.01）。血液动力学指标及心功能指标较术前组降低（P〈0.01）。复苏后EPO与LVSP、＋LVdP/dtmax、-LVdP/dtmin呈正相关,与LVEDP呈负相关,差异均有统计学意义（P〈0.01）。EPO组血液动力学及心功能指标与常规复苏组同时点比较均有改善（P〈0.01）。结论重大创伤应激可促使血清中EPO在短期内表达增多;内源性EPO大量消耗可能是复苏后心功能不全的发病机制之一;外源性补充EPO可明显改善复苏后心功能不全。

英文摘要：

Objective To study and observe the expression of Erythropoietin （EPO） in cardiopulmonary resusci‐tation （CPR） and intervention of EPO on cardiac dysfunction after the recovery .Method 72 SD rats were divided randomly into 3 groups ,sham operation group （S group） ,conventional CPR group （C group） and erythropoietin group （EPO group） ,respectively .Each group was divided into four subgroups ,0 h ,2 h ,4 h and 6 h subgroups , and each subgroup has 6 SD rats .Arterial puncture ,tracheotomy and the ordinary oxygen （3 L/min） were per‐formed in S group ,whereas ,artery and vein puncture ,tracheotomy ,invasive mechanical ventilation and cardiopul‐monary resuscitation （CPR） were performed in C and EPO groups . Heart rate （HR） ,mean arterial pressure （MAP） ,left ventricular systolic peak pressure （LVSP） ,left ventricular end‐diastolic pressure （LVEDP） and left ventricular maximum rising and falling rate （＆#177; LVdP/dtmax） of each rat were detected in each subgroup .Result EPO values increased gradually with the increase of invasive operation time in each time point in S group ,which were different （P〈0 .05） from that in preoperative group ,meanwhile ,hemodynamic values or cardiac function val‐ues were a bit higher than that in preoperative group ,however ,the values were not different （P〉0 .05） from that in preoperative group .EPO values in CPR group increased and then decreased ,and the values in 2 h and 4 h sub‐groups were significant different （P〈0 .01） from that in preoperative group after recovery .Hemodynamic values and cardiac function values in S group significantly decreased （P〈0 .01） compared with that in preoperative group . After recovery ,the values in EPO group correlated positively with LVSP ,＋LVdP/dtmax and‐LVdP/dtmin （P〈0 .01） ,whereas ,the values correlated negatively with LVEDP （P〈0 .01） .Hemodynamic values and cardiac func‐tion values in the same time point in EPO group were improved to be better tha