中文摘要：

帕金森病（Parkinsons disease，PD）是常见的神经退行性疾病，目前对PD的药物治疗仅限于改善症状，尚缺乏能够延缓疾病进程并具有神经保护作用的药物。α-突触核蛋白（α-synuelein，α-syn）是一种位于神经元突触前末端、由140个氨基酸组成的蛋白质，它的突变、聚集和过度积累与包括PD在内的一系列神经退行性疾病密切相关。开发针对α-syn及其相关靶点的药物，可能是控制PD等突触核蛋白病进程的有效途径。该文主要从抑制α-syn表达和聚集、促进其解聚和降解、调节其修饰状态等方面，对以α-syn为靶点的药物研究进展进行综述。

英文摘要：

Parkinson＇s disease （PD） is a common neurodegen- tein consisting of 140 amino acids and located in presynaptic ter-erative disease. At present, the anti-Parkinson＇ s disease drugs minals in the CNS. The mutation of α-syn gene and the aggrega-merely improve the motor symptoms, and still lack disease-modi-tion or excessive accumulation of α-syn proteins are key factors fying and neuroprotective effects, α-Synuclein （α-syn） is a pro-involved in a series of neurodegenerative diseases including PD.sion and aggregation, promoting its depolymerization and degra- dation and regulating its modification status.