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中文摘要：
目的根据硬X射线衍射增强成像工作原理,利用其图像的空间高分辨率和高相位衬度特征,对实验所获得的大鼠正常肝图像及肝纤维化图像进行纹理特征分析,探求其微观结构变化,为计算机辅助诊断提供新手段。方法本次实验在北京同步辐射装置（BSRF）4W/1A光束线形貌站完成,样品为离体大鼠正常肝及由人血白蛋白诱导的免疫损伤性肝纤维化标本,记录介质为FujiIX80胶片。本文计算了感兴趣区域图像的纹理特征参数,以及计算同一类型不同纹理参数间的相关系数,对纹理参数的波动趋势进行了初步分析。结果结果表明,正常及肝纤维化组织在相衬图像上差异较明显,可以通过逆差距、惯量、差的均值以及差的熵这四种纹理参数区分开,其中,后三种纹理参数的波动趋势类似,与逆差距正好相反。结论基于硬X射线衍射增强原理的肝纤维化图像可以通过分析纹理特征来识别其病变,可以用于辅助医生诊断。
英文摘要：
Objective Hard X-ray diffraction enhanced imaging （DEI） is a promising technique for observing biological soft tissues with its high spatial resolution and phase contrast. This study was carried out to analysis texture measurements of hepatic fibrous sample based on DEI images, and search changes in microstructural to provide a new method for computer diagnoses. Methods At the topography station of Beijing synchrotron radiation facilities （BSRF） , we implemented DEI method in normal rat liver section and hepatic fibrous sample, a series of DEI images were recorded by the X-ray films. Results Texture measurements and pearson＇s correlation coefficient of the DEI images were calculated. It is demonstrated that there are four texture measurements, inverse difference moment, inertia, difference average and difference entropy can distinguish between normal and fibrous liver tissues of rat liver sections. Conclusion We can distinguish fibrous liver tissues of rat liver according to the texture measurements of DEI images, and it offers a potential .method for doctors＇ diagnoses.
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A new method of detecting interferogram in differential phase-contrast imaging system based on speci
Noninvasive visualization of microvessels using diffraction enhanced imaging, European Journal of Ra
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