中文摘要：

目的通过观察多巴胺D1受体（Dopamine D1 Receptors，D1DR）和多巴胺D2受体（Dopamine D2 Receptors，D2DR）拮抗荆对运动疲劳后纹状体神经元电活动的影响，揭示DA系统对运动疲劳后纹状体腹外侧和背外侧神经元电活动的调节作用机制。方法10天递增负荷游泳运动建立大鼠运动疲劳动物模型。采用玻璃微电极胞外记录技术，观察右脑室（A：0mm，L：1．6min，H：3．4mm）微量注射DA受体拮抗荆SCH23390和Spiperone 10μL前、后神经元电活动的变化。结果（1）对照组有28．57％的神经元受到SCH23390的影响，其中使神经元自发放电频率加快兴奋性增加的占16．67％（7／42），兴奋性降低的占11．90％（5／42）；SCH23390的诱发作用有一定的潜伏期，且能诱发单放电神经元产生爆发式放电；（2）Spiperone记录中，56．10％的神经元兴奋性受影响，兴奋性增加的占9．76％（4／41），降低的占46．34％（19／41）。spiperone对实验组放电神经元产生抑制作用的比例显著高于兴奋作用的神经元（P〈0．05）。结论运动疲劳后SCH23390可诱发神经元单放电向爆发式放电的转变，Spiperone对纹状体神经元的抑制作用加强。

英文摘要：

Objective After the observation of the effect given by dopamine receptor antagonist on ventrolateral and dorsolateral striatum neuron electrical activity in the wake of exercise - induced fatigue, and it is revealed that there is regulation mechanism of dopamine system. Methods load - increasing swimming exercise for ten days for establishing exercise - induced fatigue model. During the experiment , the steady firing was recorded with glass mieroelectrode, SCH23390 and Spiperone （10 μL） were injected to the right ventricle （A ：0 mm, L：1. 6 mm, H：3.4 mm）and then to investigate the firing chan-es. Results 1 ） About 28.57% of neurons affected by SCH23390 in the control group, Among them there were 16.67% （7/42） neuron excitability increased, while 11.90% （5/42）decreased. There was certain latent period in SCH23390＇ s regulation role, and SCH23390 can induce single firing to bursting firing. 2） About 56.10% of neurons affected by Spiperone, Among them there were 9.76% （4/41） neuron excitability increased, while 46.34% （ 19/41 ） decreased. In experimental group, the effect of Spiperone on the discharge of neurons, the inhibitory effects were significantly higher than the excitatory effects （ P 〈 0.05 ）. Conclusion After exercise - induced fatigue, SCH23390 can induce the change from single firing to bursting firing. Spiperone can enhance the inhibitory effects on striatum neurons.