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中文摘要：
目的：研究脑乳酸在运动性疲劳发生过程中的作用机制。方法：采用微透析活体检测技术，观察力竭运动过程中大鼠纹状体乳酸浓度的动态变化，通过脑室注射乳酸阻断剂（4－CIN），观察脑内乳酸干预对大鼠运动耐力及皮层脑电（ECoG）的影响。结果：大鼠纹状体胞外乳酸浓度在运动初期显著升高（P〈0．05），在运动后期直至疲劳后的恢复期均显著低于安静时水平（P〈0．05，P〈0．01）；运动过程中，大鼠4-CIN脑室注射后20min皮层脑电功率谱总功率迅速下降，显著低于人工脑脊液（aCSF）对照组（P〈0．05），脑乳酸阻断组大鼠运动至力竭平均时间显著低于对照组（P〈0．01）。结论：脑乳酸在运动性疲劳的发生过程中发挥着重要作用，脑乳酸代谢不足可能是导致运动性疲劳出现，机体运动能力降低的主要原因之一。
英文摘要：
Objective： The aim of this research is to study the mechanism of brain lactate in the development of exercise-induced fatigue. Methods： Coupling of microdialysis and electrochemical detection technique was used for the on-line analysis of extracellular lactate in rats＂ striatum during exhaustive exercise. Ventricle micro-injection method was applied to study the effect of 4-CIN on the exercise ability and electrocorticogram of rats. Results ： Striatum extracellular lactate of rat significantly increased at the begging of exercise （P〈0.05） and it decreased significantly during the ｜ater exercise time and recovery time （P〈0.05, P〈0.01 ） ; 4-CIN can significantly reduce the power of electrocorticogram in the process of exercise （P〈0.05） and decrease the exercise time of rats （P〈0.01）. Conclusion： Brain lactate plays the important role in the development of exercise-induced fatigue. Lacking of lactate may be one of the important reasons which caused the exercise-induced fatigue.
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