中文摘要：

目的：记录并观察大鼠在一次力竭运动过程及恢复期皮层运动区皮层脑电（Electro—corticogram，ECoG）的变化特征，揭示运动性疲劳形成的中枢机制。方法：通过神经电生理学皮层脑电记录方法，记录大鼠在一次性力竭跑台运：为过程中及恢复期皮层运动区的ECoG，动态分析运动性疲劳形成和恢复过程中ECoG频率谱、功率谱的变化特征。结果：大鼠在一次性运动疲劳的形成和恢复过程中ECoG特征会发生显著变化，运动状态下ECoG功率谱总功率显著高于安静状态（P〈0．05），在6～9Hz频段出现密集的高能量分布；大鼠疲劳状态下运动ECoG功率谱频率分配与非疲劳状态下运动具有显著性差异（P〈0．05），表现为δ波比例显著增加，而α波比例显著下降（P〈0．05）。力竭即刻频率分配与运动前安静状态差异显著，表现为δ波比例显著增加，θ波比例显著下降（P〈O．05），但在30min恢复期后，频率分配恢复至运动前的状态；在力竭运动过程中大鼠ECoG功率谱重心频率逐渐向低频迁移，在力竭前10min显著低于运动前水平（P〈0．05），当运动停止后，重心频率即向高频迁移，30min即恢复至运动前水平。结论：运动性中枢疲劳的形成是一个连续累积的过程，大鼠ECoG在运动性疲劳的形成和发展过程均伴随着占节律比例的显著增加，提示，慢波艿节律可能是运动性疲劳的重要中枢机制之一。同时，运动疲劳所导致的ECoG变化恢复非常迅速，运动停止后短时间内（30min）即能得到有效的恢复。

英文摘要：

Objective：The aim of this research is to study the central mechanism of exercise-in- duced fatigue by the observation of rats＇ ECoG during and after exhaustive exercise. Methods. To record the ECoG of rats during the development and recovery of exercise-induced fatigue by the Electrophysiologic method and analyze the changes of power spectrum, frequency spectrum characters of ECoG. Results： In exercise condition, the total power of ECoG power spectrum was significantly higher than that of rest condition（P-（0.05） and the main energy distribution of ECoG frequency was 6 - 9 Hz; There is significantly difference of ECoG frequency distribu- tion between exercises with and without fatigue （P 〈 3. 05）. The. δ wave increased and the a wave decreased（P〈0.05） ; Also, significant difference of ECoG frequency distribution existed between before and immediately after exhaustive exercise（P〈0.05）. As the δ wave increased and the θ wave decreased （P〈0. 05）. However, the ECoG frequency distribution recover to that of pre-exercise in 30 minutes of recovery time; The gravity frequency of ECoG continu- ously decreased during the exhaustive exercise and significantly difference occurred when the rats exhausted （P〈0. 05） ,Whereas, it recover back to pre-exercise level in 30 minutes of re- covery time. Conclusion.. The development of exercise-induced central fatigue is a gradually ac- cumulative process. Both the development and formation of central fatigue during exercise are with the δ wave increase in ECoG. The result indicated that the increase of δ wave may be an important central mechanism of exercise-induced fatigue. However, the changes of ECoG caused by exhaustive exercise could recovery soon after exhaust.