中文摘要：

利用阳极氧化反应，将一系列N-芳基吡咯电氰化，区域专一地得到吡咯氰化物2，分离收率为76％。85％．将其与叠氮化钠反应，合成了一系列具有潜在血管紧张素II受体（AT）拮抗活性的新型四唑化合物．该合成路线的原料易得，并以阳极氰化芳香氮杂环引人氰基为关键步骤，可作为在芳香氮杂环上引人四唑基团的通用合成路线．

英文摘要：

In this paper, tetrazole ring systems were sythesized by using readily available materials via anodic cyanations of suitably N-substituted pyrrole as key step. The electrooxidation of several 1-arylpyrroles was carried out in methanol containing sodium cyanide at a Pt anode in a divided cell. In all instances, replacement of a heteroaromatic hydrogen by a cyano group occurred regio-selectively, The corresponding pyrrole cyanides were obtained in yields ranging from 76% to 85%. The advantages of electrochemistry synthesis of pyrrole cyanides are as follows： the reaction condition is simple, the cost new tetrazole derivatives which may be non-peptidic compounds is low and the products is highly pure. The with＇ potential angiotensin Ⅱ antagonist properties, were synthesized by the formal [ 2 ＋ 3 ] cycloaddition of NaN3 and pyrrole cyanides.