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中文摘要：
为了得到具有核酸切割功能的人工核酸酶，设计合成了5种环三聚磷腈多齿配体，并初步检测了其对DNA的切割活性,目标化合物的结构由IR，^1HNMR，^31PNMR，^13CNMR和ESI-MS确认．在生理条件下对pUC19 DNA切割活性的初步实验结果表明，在化合物5a-5e的Cu（Ⅱ）配合物存在下，保温24h后，pUC19 DNA由Form I断裂为FormⅡ，即合成目标化合物有明显的DNA切割活性．同时，考察了配合物5b＋Cu在不同时间下对DNA的切割活性的影响．
英文摘要：
A series of muhinuclear cyclotriphosphazene ligands were synthesized and used as artificial nucle- ase enzyme model. All of these new compounds were confirmed by MS, ^1H NMR, ^31p NMR, ^13C NMR and IR. Preliminary studies on the cleavage of pUC19 DNA in the presence of metal complexes were performed. The results strongly suggest that the pUC19 DNA can be cleaved efficiently by these ligands. The effect of DNA cleavage with ligand 5b was also studied under different cleavage time.
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