目的:综述有关中药联合干细胞移植治疗溃疡性结肠炎(UC)的研究进展。方法:广泛查阅近年来国内外相关文献,对干细胞的分类、中药对干细胞的作用及两者联合移植治疗溃疡性结肠炎作用机制的实验研究、临床研究和存在的问题进行讨论和分析。结果:动物实验和临床研究表明,中药联合干细胞移植治疗UC已取得诸多成果。中药可作用于干细胞的增殖、分化及定向迁移等多方面。两者联合应用移植后,干细胞能向损伤肠道移行,并能分化为肠黏膜上皮细胞及血管内皮细胞,具有促进肠黏膜修复以及受损肠道周围微循环重建的作用。结论:中药联合干细胞移植治疗UC是一种行之有效的方法,具有广阔应用前景,但仍有许多问题亟待解决。
Objective: To review the research progress in Traditional Chinese medicine(TCM) combined with stem cell transplantation for the treatment of ulcerative colitis(UC). Methods: Extensive review of related literature at home and abroad in recent years was carried out. We discussed and analyzed the categorization of stem cells,the role of TCM on stem cells and the treatment mechanism of two combined transplantation on UC in both experimental and clinical researches. Results: Experimental and clinical studies showed that TCM combined with stem cell transplantation in the treatment of UC has made many achievements. The roles of TCM on stem cells can performance in the proliferation,differentiation and directional migration,etc. After combining application transplantation,stem cells can damage to intestinal migration and can differentiate into intestinal mucosa epithelial cells and endothelial cells and promote the bowel glues the film repair and damage to the intestinal microcirculation around reconstruction.Conclusion: Traditional Chinese medicine combined with stem cell transplantation in the treatment of UC is an effective method and has a broad application prospect,but there are still many problems to be solved.