中文摘要：

目的：观察热敏灸对失眠大鼠血清和脑干超氧化物歧化酶（ SOD）、丙二醛（ MDA）的影响，了解热敏灸治疗失眠的机制。方法：雄性SD大鼠32只，随机分为4组：正常对照组、模型组、艾灸组和热敏灸组，每组8只。采用腹腔注射对氯苯丙氨酸（ PCPA）制备失眠大鼠模型；用Ethovision XT视频跟踪系统录制大鼠活动、观察大鼠的行为学表现；用Morris水迷宫测试大鼠的学习记忆力；用分光光度计检测SOD活性和MDA含量。结果：与正常组相比，模型组大鼠昼夜节律消失；逃避潜伏期延长；SOD活性降低，而MDA含量增加。与模型组相比，热敏灸组大鼠昼夜活动节律基本恢复正常；逃避潜伏期缩短；SOD活性增高，而MDA含量下降。结论：热敏灸具有缓解失眠大鼠症状的作用，可能与其提高机体SOD活性、降低MDA含量有关；热敏灸的效果在某种程度上优于传统悬灸。

英文摘要：

Objective：To observe the effect of heat -sensitive moxibustion on the activity of superoxide dismutase （ SOD） and the content of malondialdehyde （ MDA） in the serum and brain stem of insomnia rats .Methods：32 male SD rats were divided randomly into 4 groups with 8 rats in each group , i.e.normal control group , model group , moxibustion group , heat-sensitive moxibustion group .The model was induced by para -chlorophenylalanine （ PCPA） intraperitoneal injection .The rats＆#39;behavior was regularly recorded half -hour per day with Ethovision XT video tracking system .Learning and memory abilities were evaluated with Morris water maze .SOD activity and MDA content were determined with spectrophotometer .Results：Compared with rats in normal group , model group rats showed that the sleep-wake rhythm disappeared , the escape period prolonged , and the activity of SOD reduced while the content of MDA increased.Compared with rats in model group , heat-sensitive moxibustion group rats revealed that insomnia symptoms gradually restored, the escape period shortened , and the activity of SOD increased while the content of MDA decreased .Conclusion：Heat-sen-sitive moxibustion improves insomnia symptoms , which might be related to improving antioxidative capacity .