中文摘要：

目的探讨综合性护理干预对西酞普兰治疗老年抑郁症的疗效及生活质量的影响。方法将2012年6月-2014年6月入住我院确诊的老年抑郁症患者84例作为观察对象,全部入选患者根据护理方法不同随机分为干预组和对照组,每组各42例,两组均予西酞普兰初始剂量20 mg,渐加量至40 mg,每日1次,口服,疗程6周。对照组患者行常规对症护理;干预组患者进行综合性护理干预,包括心理护理、用药护理、生活护理、安全护理、社会家庭支持干预、健康教育。结果治疗后,干预组的有效率为90.5%,对照组的有效率为73.8%,干预组的有效率显著高于对照组,且干预组的躯体功能、心理功能、社会功能、物质生活4个维度评分高于对照组,干预组HAMD评分低于对照组,差异具有统计学意义（P〈0.05）。结论对应用西酞普兰治疗老年抑郁症实施综合性护理干预措施,可以提高疗效,改善患者的生活质量,值得推广和应用。

英文摘要：

Objective To investigate the effect and affecting of comprehensive nursing intervention on the quality of life of citalopram in the treatment of senile depression. Methods From June 2012 to June 2014 in our hospital diagnosed84 patients with senile depression were selected as observation objects, all patients according to different nursing methods were randomly divided into intervention group and control group, 42 cases in each group, two groups were treated with citalopram initial dose 20 mg, gradually increased to 40 mg, 1 times daily orally a course of 6 weeks. The control group was treated with conventional symptomatic nursing for patients. The intervention group was treated with comprehensive nursing intervention, included psychological nursing, medication nursing care, life care, safety nursing,social and family support intervention, health education. Results After the treatment, the efficiency of intervention group was 90.5%, control group was 73.8%, the efficiency in the intervention group was significantly higher than that of control group, and the intervention group＇s physical function, psychological function, social function and material life of the 4 dimension score higher than those in the control group, the HAMD score of the intervention group was lower than that of the control group, with statistically significant differences（P〈 0.05）. Conclusion The comprehensive nursing intervention measures of citalopram in the treatment of senile depression can improve the curative effect, improve the quality of life of patients, is worthy of promotion and application.