中文摘要：

目的 调查重庆地区多发性硬化（MS）患者体内维生素D水平,探讨维生素D与多发性硬化发病的相关性.方法 检测120例MS患者和52例正常对照组体内血清25（OH）D水平,分别在夏季（8月）和冬季（1月）测定MS患者的血清25（OH）D水平;观察复发-缓解型多发性硬化（RRMS）患者的复发次数,对MS患者进行生活质量和残疾程度评分.结果 MS组患者血清25（OH）D水平明显低于正常对照组（P＜0.01）;组内比较,继发进展型多发性硬化（SPMS）组及原发进展型多发性硬化（PPMS）组血清25（OH）D水平均明显低于RRMS组（P＜0.01或P＜0.05）.MS患者在夏季的血清25（OH）D水平明显低于冬季血清25（OH）D水平（P＜0.01）.血清25（OH）D水平越低,RRMS患者复发次数越多（P＜0.01）,MS患者残疾程度越重（P＜0.01）,生活质量越低（P＜0.01）.结论 维生素D缺乏可能影响MS的发病和病情进展,进而影响残疾程度和生活质量.

英文摘要：

Objective To investigate the level of vitamin D in multiple sclerosis （MS） patients and to the relation- ship of vitamin D with the onset of MS. Methods We measured the 25（OH）D level in serum samples of 120 MS patients and 52 normal controls at the date of case acquisition , in Summer （August） and in winter （January） respectively. We observed the relapse number of relapsing-remitting multiple sclerosis （RRMS） patients. The expanded disability status scale（EDSS） and Multiple Sclerosis Quality Of Life-54 instrument （MSQOL-54） at the date of serum sampling were ac- cessed with each MS patient. Results The 25 （OH） D levels in MS group were significantly lower than that of the con- trol group（P〈0.01）. 25 （OH） D levels in the secondary progressive multiple sclerosis （SPMS） group（P〈0.01）and the primary progressive multiple sclerosis （PPMS） group （P〈0.05） were significantly lower than the RRMS group. The 25 （OH） D levels of MS group in winter were significantly lower than that in summer （P〈0.01）. The lower levels of 25 （OH） D was accompanied with a higher relapses （P〈0.01）, a more severer disability （P〈0.01）, and a more lower quality of life （P〈0.01） in MS patients. Conclusion Vitamin D deficiency may affect the onset and the progression of MS, thereby affecting the severity of disability and quality of life.