中文摘要：

目的：观察缬沙坦对慢性压力超负荷下左心室心肌多聚二磷酸腺苷（ADP）核糖合成酶（PARP）活性、心脏形态及心功能的影响。方法：Wistar雄性大鼠34只随机分为假手术组（sham组）10只、腹主动脉缩窄组（AC组）12只、腹主动脉缩窄加缬沙坦干预结扎组（Val组）12只。术后24周行心脏超声和血流动力学检查,并取左心室心肌检测PARP活性。结果：与sham组比较,AC组PARP活性显著增强（P〈0.01）,左心室质量/体重（LVW/BW）显著升高（P〈0.05）,左心室射血分数显著降低（P〈0.05）;与AC组比较,Val组PARP活性显著减弱（P〈0.01）,LVW/BW显著降低（P〈0.05）,左心室射血分数明显升高（P〈0.05）。结论：缬沙坦可抑制压力负荷下心室肌PARP过度激活,并减轻心室重构及心功能的损害。

英文摘要：

Objeetive：To study the effect of valsartan on PARP activition and myocardial remodeling in the left ventricle of the rat undergoing chronic pressure overload. Method： Thirty rats were randomly divided into 3 groups, as the sham operation group sham group, （n= 10）, the abdominal aorta constriction group （AC group, n =12）, and the AC＋valsartan group （Val group, n = 12）. Transthoracic echocardiography and homodynamic were performed. PARP activity of the model rats was detected. Result：Compared with the sham group, PARP activity and LVW/BW increased significantly in the AC group （P〈0.05）. Compared with the AC group, PARP activity and LVW/BW were decreased while ejection fraction of left ventricular increased significantly in the Val group （P〈0.05）. Conclusion：Valsartan could inhibit abnormal PARP activation and ventricular remodeling in rat undergoing chronic pressure overload.