以钯为催化剂,利用便宜易得的二甲亚砜为氧化剂和溶剂,通过炔酰胺的氧化反应,高效合成了一系列α-酮酰胺衍生物.通过~1H NMR,~(13)C NMR,IR和HRMS对产物结构进行了表征.该方法具有反应条件温和、操作简单、原料易得、反应迅速的特点.
A series of α-ketoamide derivatives were obtained from the palladium catalyzed oxidation of ynamides using cheap and readily available dimethyl sulfoxide as oxidant and solvent under room temperature. The structures of all products were characterized by 1H NMR, 13 C NMR, IR and HRMS. This protocol has some distinct advantages of mild conditions, simple work-up, readily available starting materials and fast reaction rate.