放射生物剂量学方法在历次放射事故应急处置中起到非常重要的作用,主要采用非稳定性染色体畸变和微核分析。最近的研究关注快速高通量的生物剂量计的探索,不仅涉及上述方法的自动化,还涉及DNA双链断裂、基因表达等分子生物学剂量计的研究以及代谢组学和血清学指标的筛选。笔者主要就2012—2014年放射生物州量学研究的新进展进行综述。
Radiation biodosimetry plays an important role in the medical treatment of each radiation accident, mainly by dicentric and cytokinesis-block micronucleus(CBMN) analyses. Biodosimetry studies focus on the rapid and high-throughput radiation biodosimeter. These studies include not only the automatic analyses of dicentrie and CBMN, but also the molecular markers, such as DNA double-strand break and gene and protein expression. Metabolomic and serology analyses are also explored. The new progress in radiation biodosimetry over the past three years was reviewed in this paper.