中文摘要：

艰难梭菌是引起伪膜性肠炎的致病菌。目前国内外均出现了同时耐两种主要治疗药物——甲硝唑、万古霉素的菌株，疫苗研究是防治艰难梭菌的重要手段。国外研制艰难梭菌疫苗近20年，取得了一定进展，本文将对现有的艰难梭菌疫苗的研究现状进行总结，并对疫苗的发展进行展望。

英文摘要：

Clostridium difficile（CD） is the pathogen of pseudomembranous colitis （PMC）. Metronidazole and Vancomycin are the major treatment drugs for PMC. However, clostridium difficile has been found to possess multiple-antibiotic resistant genes and clostridium difficile clinical isolates resistant to both Vancomycin and Metronidazole have been reported, which increase the difficulty for treatment of clostridium difficile in the future. For all these reasons, the study of vaccine against CD is very important. The vaccines against clostridium difficile have been studied in abroad for almost 20 years and great progress has been achieved in the study of clostridium difficile vaccine. In this article we will have a review of the clostridium difficile vaccine.