药物相关线索反应是成瘾行为的重要标志,它直接导致心理渴求和强迫性的刺激-反应式自动化用药行为。其神经机制是包含了经典和操作条件反射的联结学习。在联结过程中,除奖赏系统外,感觉-动作系统在相关线索反应中也起到了重要作用。其机理可能是与感觉运动脑区部分重合的镜像神经的理解、分析和推测动作意图目的以及内隐模仿的功能有关。另外,动作记忆的形成及功能也可能在这种自动化动作图式的形成中起到了重要的作用。其确切的机制需要进一步研究证据。
Drug cue-related reactivity is an important mark of drug addiction. It results in stimulus-response craving and compulsive drug use. The neurobiological mechanism of this compulsive behavior is the stimula-automatized action schemata, which is the result of association learning, including classic and operant conditioned reflex. Recent research indicates that the function of the mirror neuro system which overlaps part of the sensory-motor brain regions and have been known to help with understanding actions, analysis, inferring intentions and goals of the actions, inner imitating, may facilitate the formation of automatized action schemata and result in repeated drug use and relapse. In addition, there is evidence that the action memory's mechanism and function play an important role in the processing of automatic action.