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细胞生物学及发育生物学
  • 项目名称：细胞生物学及发育生物学
  • 项目类别：国家杰出青年科学基金
  • 批准号：39625015
  • 申请代码：C07
  • 项目来源：国家自然科学基金
  • 研究期限：1997-01-01-1999-12-31
  • 项目负责人：裴钢
  • 负责人职称：研究员
  • 依托单位：中国科学院上海生命科学研究院
  • 批准年度：1996
中文摘要：

细胞生物学及发育生物学

中文主题词： 阿片受体，信号转导，趋化因子受体，
结论摘要：

英文主题词opioid receptor, signal transduction, chemokine receptor

成果综合统计
成果类型
数量
  • 期刊论文
  • 会议论文
  • 专利
  • 获奖
  • 著作
  • 75
  • 2
  • 0
  • 0
  • 0
期刊论文
Inhibition of phospholipase C blocks opioid receptor-mediated activation of Gi proteins
Differential neurotoxicity of etorphine-like opiates:Lack of correlation with their ability to activ
Analgesic effect of agmatine and its enhancement on morphine analgesia in mice and rats
The amino terminus with a conserved glutamic acid of G protein-coupled receptor kinases in indispens
Modulation of protein kinase C and cAMP-dependent protein kinase by δ-opioid
Differential efficacies κagonists to induce homologous desensitization of human κ opioid receptor
Endogenous opioid receptro-like receptor in human neuroblastoma SK-N-SH cells:activation of inhibito
Modulation of alcium/calmodulin-dependent protein kinase II activity by acute and chronic morphine a
Five-transmembrane domains appear sufficient for a G protein-coupled receptor:functional five-transm
Modulation of protein kinase C and cAMP-dependent protein kinase by -opioid.
Carboxyl terminal of rhodopsin kinase in required for the phosphorylation of photo-activated rhodops
Attenuation of nociception/orphanin FQ-induced signaling by N-emthyl-D-aspartate in neuronal cells
Suppression of phospholipase C blocks Gi-mediate inhibition of adenylyl cyclase activity
Attenuation of nociceptin/ orphanin FQ-induced signaling by N-methyl-D-aspartate in neuronal cells.
Functional expression, activation and desensitization of opioid receptor-like recept or ORL1 in neur
Modulation by calcium/ calmodulin-dependent protein kinase II of functional response of delta opioid
Inhibition of phospholipase C blocks opioid receptor -mediated activation of Gi proteins.
Differential efficacies ( agonists to induce homologous desensitization of human ? opioid receptor.
Antisense oligonucleotide to insulin-like growth factor II induces apoptosis in human ovarian cancer
Nongenomic mechanisms of glucocorticoid inhibition of nicotine-induced calcium influx in PC12 cells:
Agmatine inhibited tolerance to and dependence on morphine in guinea pig ileum in vitro.
Qin BY. Analgesic effect of agmatine and its enhancement on morphine analgesia in mice and rats.
Attenuation of morphine tolerance and dependence in scopolamine-treated rats.
Modulation of calcium/ calmodulin-dependent protein kinase II activity by acute and chronic morphine
人类(-arrestin1 cDAN 的克隆、表达及功能的研究。
人类β-arrestinl cDNA的克隆、表达及功能的研究
N-Methyl-D-asparatate attenuates opioid receptor-mediated G protein activation and this process invo
Agmatine inhibited tolerance to and dependence on morphine in guinea pig ileum in vitro
Activation of p38 mitogen-activated protein kinase by oxidized LDL in vascular smooth muscle cells:m
Attenuation of morphine tolerance and dependence in scopolamine-treated rats
Acute desensitization of nociception/orphanin FQ inhibition of voltage-gated calcium channels in fre
Etorphine inhibites cell growth and induces apoptosis in SK-N-SH cells:involvement of pertussis toxi
Moudulation by calcium/calmodulin-dependent protein kinase II of functional response of delat opioid
Chemokine receptor CCR5 functionally couples to inhibitory G proteins and undergoes desensitization
Selective interference of beta-arrestin l with kappa and delta but not mu opioid receptor/G protein
Attenuation of delta opioid receptor-mediated signaling by kainic acid in neuronal cells:involvement
Inhibition of calcium/calmodulin-dependent protein kinase II in rat hippocampus attenuates morphine
Endogenous delta-opioid and ORL l receptors coupe to phosphorylation and activation of p38 MAPK in N
Activation of N-methyl-D-aspartate receptor attenuates acute responsiveness of delta-opioid receptor
Functional expression activation and desensitization of opioid receptor-like recept or ROL l in neur
Molecular characterization and functional expression of opioid receptor-like receptor
Retardation of pain development:a case of recovery from congenital insensitivity to pain
Progesterone induces apoptosis and up-regulation of p53 expression in human ovarian cancer cell line
The carboxyl terminus of mouse delta-opioid receptor is not required for agonist-dependent activatio
Carboxyl terminus of mitosin is sufficient to confer spindel pole localization
Nociceptin/orphanin FQ activates protein kinase C and this effect is mediated through phospholipase
Identification of alternative splicing variants of the (-subunit of human Ca2 /calmodulin-dependent
Lysophosphatidycholine Activates p38 and p42/44 Mitogen- Activated Protein Kinases in Monocytic THP-
Identification of alternative splicing variants of the β-subunit of human Ca2 /calmodulin-dependent
会议论文
Selective interference of beta-arrestin 1 with kappa and delta but not mu opioid receptor/G protein
Nociceptin/orphanin FQ stimulates extracellular acidification and desensitization of the response in
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裴钢的项目
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2005年国际干扰素和细胞因子年会
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期刊论文 13 获奖 4
神经细胞中多种信号转导体系间相互作用的分子机理
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