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中文摘要：
本项目着重研究了阿片和NMDA受体媒介的信号转导体系间在神经细胞中相互作用的几个重要交叉点，并深入探讨了这些相互作用的分子机理和对神经细胞功能的影响。揭示了阿片受体受到反馈调控的详细机制；证明NMDA对阿片受体介导的信号转导相互作用是由其受体、通过提高细胞内钙离子浓度并激活PKC而实现的；发现阿片受体和孤啡肽受体的激活能引起细胞内p42和p44 MAPK的磷酸化和激活；并进一步研究了其他受体系统与G蛋白偶联受体的相互作用的方式和机制；从而从各个方面全面地阐明了神经细胞处理同时存在的多种细胞外信息的调节和整合机理。
结论摘要：
英文主题词Neurocyte; G protein-coupled receptor; signal transduction
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期刊论文
Endogenous opioid receptor-like receptor in human neuroblastoma SK-N-SH cells: activation of inhibit
Nociceptin/orphanin FQ stimulates extracellular acidification and desensitization of the response in
Carboxyl terminus of delta opioid receptor is required for agonist-dependent receptor phosphorylatio
Nociceptin/orphanin FQ activates protein kinase C, and this effect is mediated through phospholipase
Functional expression of opioid receptor-like receptor and its endogenous specific agonist nocicepti
Differential neurotoxicity of etorphine-like opiates: Lack of correlation with their ability to acti
Chemokine receptor CCR5 functionally couples to inhibitory G proteins and undergoes desensitization.
Carboxyl terminal of rhodopsin kinase is required for the phosphorylation of photo-activated rhodops
Nociceptin/Orphanin FQ activates mitogen-activated protein kinase in Chinese Hamster ovary cells exp
N-Methyl-D-aspartate attenuates opioid receptor-mediated G protein activation and this process invol
Attenuation of delta opioid receptor-mediated signaling by kainic acid in neuronal cells: involvemen
Five-transmembrane domains appear sufficient for a G protein-coupled receptor: functional five-trans
Anti-HIV agent trichosanthin enhances the capabilities of chemokines to stimulate chemotaxis and G p
Inhibition of calcium/calmodulin -dependent protein kinase II in rat hippocampus attenuates morphine
Endogenous delta-opioid and ORL1 receptors couple to phosphorylation and activation of p38 MAPK in N
The amino terminus with a conserved glutamic acid of G protein-coupled receptor kinases is indispens
Acute desensitization of nociceptin/orphanin FQ inhibition of voltage-gated calcium channels in fres
Lysophosphatidycholine Activates p38 and p42/44 Mitogen-Activated Protein Kinases in Monocytic THP-1
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