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中文摘要：
黄精凝集素II(PCL II)是从我国传统中草药中分离的具有多种生物学活性（特别是对HIV I/II强烈的抑制作用）的单子叶甘露糖、唾液酸结合凝集素，在前期对 PCL II 基因克隆、序列分析比较和定点突变研究的基础上,高效表达并纯化 PCL II 及其糖结合位点的不同突变体, 研究获得PCL II及其活性相关突变体以及它们与特异结合糖配体复合物的晶体, 利用X-射线晶体衍射技术测定它们的三维结构，系统研究影响配体复合物和突变体特征功能变化的主要结构因素，揭示PCL II功能活性发挥的结构基础，阐明其特殊的生物学功能与三维结构的关系，研究结果将为了解相关疾病的机理及相关药物设计提供分子水平的理论基础。
结论摘要：
英文主题词PCLII;mutants of PCL II in mannose-bingding sites; complexs of PCL II and mutants with mannose and sialic acid; crystal structure
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