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中文摘要：
核酸在细胞信号转导过程中起着重要作用，本项目拟针对特殊结构核酸和相关蛋白，通过化学小分子与它们的相互作用来探索和调控细胞相关信号转导过程，揭示生命过程规律，推动生物学和医药行业的发展。将在原有的研究基础上，对G-四链核酸和环核苷酸在细胞信号转导中的作用进行深入研究1）设计合成能对四链核酸结构具有识别作用的化学小分子，研究它们对四链核酸构像转变的调控和与核酸、相关蛋白间的关系和分子作用机理，建立阻断G-四链核酸与结合蛋白相互作用的抗肿瘤药物设计的新策略。2）利用化学小分子探针和相关技术，研究端粒相关信号转导通路中各重要环节的关键端粒相关蛋白之间的相互作用，发现和鉴定信号转导网络的新组分，揭示以端粒体蛋白为中心的新的信号转导通路和功能调控网络。3）利用化学小分子和RNAi策略从与钙信号释放相关的基因中筛选与与cADPR介导的钙信号调控相关蛋白，并建立药效团模型。
结论摘要：
英文主题词Nucleic Acids；ligand；cell signaling；epigenetic modification；regulation
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期刊论文
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