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中文摘要：
本项目以离体神经细胞和在体蛛网膜下腔出血（SAH）模型为对象，联合应用多种技术手段和方法，探讨了SAH后脑淋巴引流途径在继发性脑缺血中的作用。（1）建立了定性及定量评估脑及蛛网膜下腔中大分子物质经脑淋巴引流途径清除的方法，并发现SAH后脑淋巴引流途径相对功能不足；（2）脑淋巴引流阻滞显著加重SAH后脑脊液所致培养的海马神经元凋亡和细胞损伤；（3）脑淋巴引流阻滞明显加剧SAH后脑血管痉挛、微循环障碍、脑血流量下降、神经元凋亡和脑损伤；（4）脑淋巴引流阻滞可增强SAH后血管内皮生长因子表达和血管新生；（5）脑淋巴引流阻滞不利于内源性神经干细胞向神经元方向的分化。（6）吡哆醇、银杏内酯、银杏黄酮对脑淋巴阻滞加重的SAH后脑血管痉挛、脑损伤具有一定缓解作用。本研究阐明了脑内大分子物质的淋巴引流途径在SAH 继发脑缺血损伤中的重要作用，为后者的防治探讨提供了新的视角和方法。本项目将推动SAH及相关脑部疾病的防治研究。
结论摘要：
英文主题词subarachnoid hemorrhage;secondary cerebral ischemia;cerebral lymphatic drainage;cerebral vasospasm
成果综合统计
期刊论文
会议论文
专利
获奖
著作
期刊论文
Effects of blockade of cerebral lymphatic drainage on regional cerebral blood flow and brain edema a
Expression of the receptors of VEGF and the influence of extract of Ginkgo biloba after cisternal in
Changes of nitric oxide, oxide free radicals, and systolic arterial blood pressure in rats with expe
会议论文
GINKGO BILOBA EXTRACT INCREASES THE PRODUCTION OF HEME OXYGENASE-1 AND CARBON MONOXIDE AFTER EXPERIM
ROLE OF LYMPHATIC DRAINAGE FROM CNS IN THE DEVELOPMENT OF CEREBRAL VASOSPASM AND RELATED CEREBRAL IS
THE EFFECT OF CSF ON CULTURED TAT HIPPOCAMPAL NEURONS AFTER SUBARACHNOID HEMORRHAGE AND CEREBRAL LYM
EFFECTS OF BLOCKADE OF CEREBRAL LYMPHATIC DRAINAGE ON CEREBRAL INJURY FOLOWING SUBARACHNOID HEMORRHA
ROLE OF LYMPHATIC DRAINAGE PATHWAY IN PROLIFERATION AND DIFFERENTIATION OF NEURAL STEM CELLS IN RATS
Changes of nitric oxide, oxide free radicals, and systolic arterial blood pressure in rats with expe
EFFECT OF CEREBRAL LYMPHATIC BLOCKADE, GINKGOLIDES AND GINKGOFLAVONES AGAINST BRAIN HYDROPS AND NEUR
Effects of cerebral lymphatic drainage blockage on intracranial pressure,cerebral bllod perfusion, o
Increased production of heme oxygenase-1 and CO by Ginkgo biloba extract after cisternal injection o
ALTERATIONS OF INTRACRANIAL PRESSURE, CEREBRAL BLOOD PERFUSION, OXYGEN FREE RADICALS, AND THE INFLUE
Role of lymphatic drainage from CNS in the development of cerebral vasospasm and related cerebral is
Evaluation of the clearance of macromolecular tracers from CSF by lymphatic pathway in a rat model o
CEREBRAL LYMPHATIC BLOCKING INCREASE THE PRODUCTION OF ENDOTHELIN-1 IN CSF AFTER EXPERIMENTAL SUBARA
ALTERATIONS OF rCBF OF CAUDATE NUCLEUS AND EXPRESSION OF FAS L BY CEREBRAL LYMPHATIC BLOCKADE, AND T
EFFECTS OF CEREBRAL LYMPHATIC DRAINAGE PATHWAY ON CEREBRAL VASOSPASM AND CEREBRAL ISCHEMIC INJURY AF
EFFECTS OF BLOCKADE OF CEREBRAL LYMPHATIC DRAINAGE ON CEREBRAL ISCHEMIC INJURY SECONDARY TO SUBARACH
CERETRAL DISTRIBUTION OF INTRNASAL ADMINISTRATION OF RECOMBINANT HUMAN GRANULOCYTE COLONY-STIMULATIN
EVALUATION OF THE CLEARANCE OF MACROMOLECULAR TRACERS FROM CSF BY LYMPHATIC PATHWAY IN A RAT MODEL O
THE EFFECTS OF CIRCULATING ENDOTHELIAL CELLS ON SUBARACHNOID HEMORRHAGE BY INTRANASAL DELIVERY OF CA
Cervical Lymphatic Blokage Aggravates the Injury of Cultured Neurons by CSF from rabbit with Subarac
Expression of the receptors of VEGF and the influence of extract of Ginkgo biloba after cisternal in
Effects of blockade of cerebral lymphatic drainage on regional cerebral blood flow and brain edema a
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