欢迎您！东篱公司
退出
-
申报数据库
-
立项数据库
-
成果数据库
-
项目获奖数据库
位置：立项数据库 > 立项详情页
中文摘要：
有机合成化学是化学研究的核心内容之一，不仅是活性物质合成和新药发现的科学基础，还为衣、食、住、行和社会发展提供物质保障。它与材料科学、生命科学和人类健康等有紧密的联系。因此,开展有机合成化学研究，研究新反应、新方法、新策略和具有重要生物活性复杂分子的合成，具有重要的理论意义和应用前景。以有机合成的新反应和新策略为主线，针对有机合成化学存在的重要科学问题，按照有机合成化学的可控性、针对性和有效性等原则，设计和合成新型高效催化剂，开展不对称催化反应、酶及模拟酶催化反应研究、尤其是新反应、新策略及相关反应的理论模拟研究，发展高效、简洁和环境友好的合成途径和策略，并将合成方法学研究成果应用于具有重要生物功能分子的合成。同时，对具有重要生物功能的复杂天然产物分子进行全合成研究，在全合成研究中发展新的方法和策略，促进有机合成化学的发展。
英文摘要：
Novel Catalyst；Biocatalysis；New Synthetic Method；New Synthetic Strategy；Total Synthesis
结论摘要：
项目按照预定的研究方向，在有机合成新催化剂、新反应和新策略、生物催化与仿生催化研究、天然产物全合成研究方面取得系统性研究结果，达到了预期目标。项目发展了具有自主知识产权的高效催化剂，如手性双氮氧-酰胺和胍-酰胺配体和催化剂，用之实现了7类不对称催化新反应，其中之一被有机人名反应专著收录冠名为Roskamp–Feng反应。设计并首次实现的手性胺通过三烯胺机制的不对称Diels？Alder反应，实现了远端手性控制。开展水解酶催化非专一性的研究，扩展了水解酶催化C–C(N)键形成的反应体系。通过发展新型、高效、高选择性的杂芳环C–H键直接官能化反应合成多样化的杂芳环化合物，为构筑基于芳杂环的荧光核心骨架提供了便捷、高效的合成策略。首次完成了吲哚生物碱(+)-perophoramidine、倍半萜Onoseriolide和二倍半萜Bolivianine、树脂糖苷二聚体batatin VI等的全合成，以及毒扁豆碱衍生物、甲酰阿地咪、钩吻碱、愈创木内酯二聚体等的高效合成。围绕新试剂如偕双硅化合物的多样性高效合成、性质和功能的探索也取得显著成果。本项目执行期间共发表SCI论文230篇，其中影响因子大于6的124篇，包括Acc. Chem. Res. 3篇，Chem. Rev. 1篇，Chem. Soc. Rev. 1篇，J. Am. Chem. Soc. 11篇，Angew. Chem. Int. Ed. 24篇，Adv. Funct. Mater. 1篇，Chem. Sci. 6篇，Chem. Commun. 21篇，Org. Lett. 26篇，Chem. Eur. J. 28篇，Green Chem. 2篇。授权中国发明专利18项，参编专著3章节。获国家自然科学奖二等奖1项(2012年)。在国际及双边学术会议作邀请报告20人次；国内学术会议邀请报告11人次。参与承办了国内外学术会议3次；新增中国科学院院士1人，国家杰出青年基金获得者2人，百篇优秀博士论文指导教师2人，国家级教学名师1人，863项目首席专家1人，优秀青年基金获得者2人，教育部新世纪人才计划2人。项目已培养(毕业)硕士研究生53人，博士研究生50人。
成果综合统计
期刊论文
会议论文
专利
获奖
著作
期刊论文
[1,4]-S- to O-Silyl Migration: Multicomponent Synthesis of a-Thioketones through Chemoselective Tran
[1,5]-Anion Relay/[2,3]-Wittig Rearrangement of 3,3-Bis(silyl) Allyl Enol Ethers: Synthesis of Usefu
A highly stereoselective approach to tetrasubstituted (E)-b-hydroxy silyl enol ethers by addition of
New Electrophilic Addition of alpha-Diazoesters with Ketones for Enantioselective C-N Bond Formation
Recent progress in enantioselective synthesis of C3-functionalized oxindoles: rare earth metals take
[1,5]-Brook rearrangement: an overlooked but valuable silyl migration to synthesize configurationall
Aromatic C-N bond formation via simultaneous activation of C-H and N-H bonds: direct oxyamination of
Computational investigation on the mechanism and stereochemistry of guanidine-catalyzed enantioselec
Enantioselective aza-Michael reaction of hydrazide to chalcones through the nonactivated amine moiet
Asymmetric 1,2-Reduction of Enones with Potassium Borohydride Catalyzed by Chiral N,N '-Dioxide-Scan
Synthesis of 3-substituted 8,9-didehydroazepino[4,5-b]indolines via ring expansion reaction of pyrro
Catalytic Asymmetric Homologation of alpha-Ketoesters with alpha-Diazoesters: Synthesis of Succinate
Catalyst-free and solvent-free Michael addition of 1,3-dicarbonyl compounds to nitroalkenes by a gri
Asymmetric Synthesis of cis-4-Aminobenzopyran Derivatives Catalyzed by N,N '-Dioxide-Sc(OTf)3 Comple
Chiral guanidine-catalyzed asymmetric direct vinylogous Michael reaction of alpha,beta-unsaturated g
Au(I)-N-heterocyclic carbene complex-catalyzed synthesis of 1-substituted benzo[b][1,4]diazepines fr
exo-Selective Asymmetric Diels–Alder Reaction of 2,4-Dienals and Nitroalkenes by Trienamine Catalysi
Asymmetric Synthesis of beta-Amino Nitriles through a Sc-III-Catalyzed Three-Component Mannich React
An Asymmetric Allylic Alkylation-Smiles Rearrangement-Sulfinate Addition Sequence to Construct Chira
Asymmetric aza-Diels–Alder and Cation–olefin Cyclization Sequence: a Concise Way to Fused Chiral Cyc
Aminocatalytic Asymmetric exo-Diels–Alder Reaction with Methiodide Salts of Mannich Bases and 2,4-Di
A Theoretical Investigation on the Strecker Reaction Catalyzed by a Ti-IV-Complex Catalyst Generated
Asymmetric alpha-Amination of 4-Substituted Pyrazolones Catalyzed by a Chiral Gd(OTf)(3)/N,N '-Dioxi
Indium(III)-Catalyzed Asymmetric Hetero-Diels-Alder Reaction of Brassard-Type Diene with Aliphatic A
Tuning Effect of Silyl Protecting Groups on the Glycosylation Reactivity of Arabinofuranosyl Thiogly
One-pot synthesis of branched oligosaccharides by use of galacto- and mannopyranosyl thioglycoside d
A Diastereoselective Cyclic Imine Cycloaddition Strategy To Access Polyhydroxylated Indolizidine Ske
Regioselective Glycosylation Method Using Partially Protected Arabino- and Galactofuranosyl Thioglyc
Facile Access to 3-Acylindoles through Palladium-Catalyzed Addition of Indoles to Nitriles: The One-
Direct arylation of phenanthroline derivatives via oxidative C-H/C-H cross-coupling: synthesis and d
Novel bisimidazolium pincers as low loading ligands for in situ palladium-catalyzed Suzuki-Miyaura r
A Novel Catalyst-Free Tandem Reaction for the Synthesis of 5-Hydroxy-1,5-dihydro-2H-pyrrol-2-ones in
A novel enzymatic tandem process: utilization of biocatalytic promiscuity for high stereoselective s
Organocatalytic Sequential Hetero-Diels Alder and Friedel Crafts Reaction: Constructions of Fused He
Tertiary Amine-Catalyzed Chemoselective and Asymmetric [3 + 2] Annulation of Morita-Baylis-Hillman C
Stereodivergence in Amine-Catalyzed Regioselective [4 + 2] Cycloadditions of β?Substituted Cyclic En
Asymmetric Diels–Alder reaction of b,b-disubstituted enals and chromone-fused dienes: construction o
Efficient Approach to 3,3-Bissilyl Carbonyl and Enol Derivatives via Retro-[1,4] Brook Rearrangement
Addition of TMS-Substituted Oxiranyl Anions to Acylsilanes. A Highly Stereoselective Approach to Tet
Geminal Bis(silyl) Enal: A Versatile Scaffold for Stereoselective Synthesizing C3,O1?Disilylated All
Bioinspired Total Synthesis of Bolivianine: A Diels - Alder/Intramolecular Hetero-Diels-Alder Cascad
Total syntheses of lindenane-type sesquiterpenoids: (+/-)-chloranthalactones A, B, F, (+/-)-9-hydrox
Synthesis gas production from CO2 reforming of methane over Ni-Ce/SiO2 catalyst: The effect of calci
Theoretical study on the mechanism of Pd(OAc)(2) catalyzed dehydrogenative cross-coupling of two het
Iron-Catalyzed Direct Suzuki-Miyaura Reaction: Theoretical and Experimental Studies on the Mechanism
A novel BINOL-based cyclophane via click chemistry: synthesis and its applications for sensing silve
Trienamines Derived from Interrupted Cyclic 2,5-Dienones: Remote δ,ε-CC Bond Activation for Asymmetr
Rauhut-Currier-Type Reaction with Morita-Baylis-Hillman Carbonates of 2?Cyclohexenone and Alkylidene
Palladium-catalyzed tandem N-H/C-H arylation: regioselective synthesis of N-heterocycle-fused phenan
Palladium(II)-Catalyzed Dehydrogenative Cross-Coupling between Two C-sp3-H Bonds: Unexpected C=C Bon
AConcise Assembly of Electron-Deficient 2,4-Dienes and 2,4-Dienals: Regio- and Stereoselective exo-D
Enantioselective Aza-Morita–Baylis–Hillman Reaction with Ketimines and Acrolein Catalyzed by Organic
Amine–N-heterocyclic carbene cascade catalysis for the asymmetric synthesis of fused indane derivati
Rhodium or Ruthenium-Catalyzed Oxidative C?H/C?H Cross-Coupling: Direct Access to Extended p-Conjuga
Insight into the Role of the Counteranion of an Imidazolium Salt in Organocatalysis: A Combined Expe
One-pot synthesis of benzofused heteroaryl azoles via tandem C-heteroatom coupling/C-H activation of
Prins Cyclization of Bis(silyl) Homoallylic Alcohols to Form 2,6-cis-Tetrahydropyrans Containing a G
Theoretical study on the mechanism and stereochemistry of salicylaldehyde-Al(III)-catalyzed hydropho
CO2 reforming of methane over Mg-promoted Ni/SiO2 catalysts: the influence of Mg precursors and impr
Theoretical investigation on copper hydrides catalyzed hydrosilylation reaction of 3-methylcyclohex-
Nature of vanadium species on vanadium silicalite-1 zeolite and their stability in hydroxylation rea
Organocatalytic Oxyamination of Azlactones: Kinetic Resolution of Oxaziridines and Asymmetric Synthe
Catalytic Asymmetric Addition of Alkyl Enol Ethers to 1,2-Dicarbonyl Compounds: Highly Enantioselect
Facile and Efficient Enantioselective Hydroxyamination Reaction: Synthesis of 3-Hydroxyamino-2-Oxind
Highly enantioselective yttrium(III)-catalyzed Friedel-Crafts alkylation of beta-trichloro(trifluoro
Determination of concentration and enantiomeric excess of amines and amino alcohols with a chiral ni
Highly Enantioselective Conjugate Addition of Cyclic Diketones to beta,gamma-Unsaturated alpha-Ketoe
Highly enantioselective synthesis of gamma-substituted butenolides via the vinylogous Mukaiyama-Mich
Asymmetric Crossed-Conjugate Addition of Nitroalkenes to Enones by a Chiral Bifunctional Diamine Org
Guanidine Organocatalyst for the Asymmetric Mannich-Type Reaction between alpha-Isothiocyanato Imide
Highly Enantioselective Synthesis of Tetrahydroquinolines via Cobalt(II)-Catalyzed Tandem 1,5-Hydrid
Organocatalytic Sequential Michael Reactions: Stereoselective Synthesis of Multifunctionalized Tetra
Highly Enantioselective Direct Michael Addition of 1H-Benzotriazole to Chalcones Catalyzed by Sc(OTf
Catalytic Asymmetric Chloroamination Reaction of alpha,beta-Unsaturated gamma-Keto Esters and Chalco
N,N '-Dioxide-nickel(II) complex catalyzed asymmetric Michael addition of cyclic 1,3-dicarbonyl comp
Highly Z-Selective Asymmetric Conjugate Addition of Alkynones with Pyrazol-5-ones Promoted by N,N'-D
A Catalytic Asymmetric Ring-Expansion Reaction of Isatins and a-Alkyl-a-Diazoesters: Highly Efficien
An Efficient Synthesis of a (-)-Physostigmine's Library for Identifying Potential Anti-Alzheimer's A
Towards Total Synthesis of Communesins and Perophoramidine: Unexpected Cascade Reaction of Michael-M
Recent Advances in Enantioselective Synthesis of gamma-Substituted Butenolides via the Catalytic Asy
Copper-catalyzed aerobic oxidative cross-coupling of arylamines and dialkylphosphites leading to N-a
Catalytical promiscuity of alpha-amylase: Synthesis of 3-substituted 2H-chromene derivatives via bio
Water promoted enantioselective aldol Reaction by proline-cholesterol and -diosgenin based amphiphil
Purification of porcine pancreatic lipase by aqueous two-phase systems of polyethylene glycol and po
Direct Arylation of Arene and N-Heteroarenes with Diaryliodonium Salts without the Use of Transition
Enantioselective Synthesis of 2-Substituted-1,5-Benzodiazepines through Domino Reaction of o-Phenyle
Asymmetric Iodoamination of Chalcones and 4-Aryl-4-oxobutenoates Catalyzed by a Complex Based on Sca
Nickel(II)-Catalyzed Enantioselective 1,3-Dipolar Cycloaddition of Azomethine Imines with Alkylidene
Efficient Enantioselective Synthesis of Dihydropyrans Using a Chiral N,N '-Dioxide as Organocatalyst
Asymmetric Organocatalytic Cyclopropanation of Cinnamone Derivatives with Stabilized Sulfonium Ylide
N, N'-Dioxide-Magnesium Ditriflate Complex-Catalyzed Asymmetric alpha-Hydroxylation of beta-Keto Est
Synthesis of the atropurpuran A-ring via an organocatalytic asymmetric intramolecular Michael additi
Enantioselective Baeyer-Villiger Oxidation: Desymmetrization of Meso Cyclic Ketones and Kinetic Reso
Highly Enantioselective Fluorination of Unprotected 3-Substituted Oxindoles: One-Step Synthesis of B
Developments and Applications of Coupling Reactions in Dye Discovery: Regiospecific N-Heteroarylatio
Silver-promoted Friedel-Crafts reaction: concise total synthesis of (-)-ardeemin, (-)-acetylardeemin
Asymmetric Catalytic 1,3-Dipolar Cycloaddition Reaction of Nitrile Imines for the Synthesis of Chira
Multichannel Chromogenic and Chiral Anions Recognition by Imidazolium Functionalized BINOL Derivativ
Probing the Mechanism of the Asymmetric Aminolysis of meso-Epoxides Catalyzed by a Proline-Based N,N
Active species formed in a Fenton-like system in the medium of triethylammonium acetate ionic liquid
Asymmetric Synthesis of Tetrahydroquinolines with Quaternary Stereocenters through the Povarov React
Completely OH-Selective FeCl3-Catalyzed Prins Cyclization: Highly Stereoselective Synthesis of 4-OH-
Enhancement of activity and stability of lipase by microemulsion-based organogels (MBGs) immobilizat
Asymmetric assembly of 2-oxindole and α-angelica lactone units to construct vicinal quaternary chira
Asymmetric Synthesis of 2,3-Dihydroquinolin-4-one Derivatives Catalyzed by a Chiral Bisguanidium Sal
Enantioselective Synthesis of ss-Pyrazole-Substituted Alcohols through an Asymmetric Ring-Opening Re
Trienamine Catalysis with 2,4-Dienones: Development and Application in Asymmetric Diels–Alder Reacti
Chelation-assisted Rh(III)-catalyzed C2-selective oxidative C-H/C-H cross-coupling of indoles/pyrrol
Marinopyrrole derivatives as potential antibiotic agents against methicillin-resistant Staphylococcu
Highly Enantioselective Michael Addition of Pyrazolin-5-ones Catalyzed by Chiral Metal/N,N '-Dioxide
Highly Stereoselective Conjugate Addition and -Alkynylation Reaction with Electron-Deficient Alkynes
Catalytic Asymmetric 1,3-Dipolar Cycloaddition of Nitrones to Alkylidene Malonates: Highly Enantiose
N-Oxide as a Traceless Oxidizing Directing Group: Mild Rhodium(III)-Catalyzed C-H Olefination for th
Asymmetric Cycloaddition of beta,gamma-Unsaturated alpha-Ketoesters with Electron-Rich Alkenes Catal
Catalytic asymmetric cross-dehydrogenative coupling: activation of C-H bonds by a cooperative bimeta
Sakurai Reaction of 3,3-Bis(silyl) Silyl Enol Ethers with Acetals Involving Selective Desilylation o
相关项目
冯小明的项目