中文摘要：

目的：探讨有4个跨膜区的L6超家族成员1（transmembrane 4 L six family member 1, TM4SF1）基因在上皮性卵巢癌（卵巢癌）组织中的表达及其临床价值。方法：用RT—PCR法检测TM4SFl基因在36例卵巢癌、15例卵巢良性肿瘤、13例正常卵巢组织中的表达。结果：TM4SFI基因在卵巢癌中表达为（0．173±0．054）、良性肿瘤为（0．134±0．015）、正常卵巢组织为（0．118±0．008）。癌组织中的表达水平高于卵巢良性肿瘤（P=0．031）；癌组织中的表达水平高于正常卵巢组织（P=0．004）；良性卵巢肿瘤组织中的表达水平高于正常卵巢组织（P=0．012）；手术一病理分期为I-Ⅱ期癌组织中的表达水平（0．124士0．02）低于Ⅲ期（01．164±0．024）（P〈0．05）；高分化癌组织中的表达水平为（0．091±0．052），中-低分化癌组织表达为（0．113±0．024）（P〉0．05）。结论：TM4SFl基因的表达与卵巢癌相关，可能在卵巢癌的发生、发展过程中起一定作用。

英文摘要：

Objective：To evaluate the expression of TM4SF1 gene mRNA in epithelial ovarian cancer （EOC） tissue and to explore its clinical value. Methods： The expression of TM4SF1 gene was detected by semi- quantitative RT-PCR in 13 ovarian normal tissues, 15 benign ovarian tumor tissues and 36 EOC tissues. Results： There was certain extent expression of TM4SF1 gene in EOC tissues （0. 173±0. 054）, benign o- varian tumor tissues （0. 134± 0. 015）, ovarian normal tissues （0. 118±0. 008）. The expression level of TM4SF1 gene in EOC tissues was higher than that in benign ovarian tumor tissues and ovarian normal tissues （ P 〈0.05）. The expression level of TM4SF1 gene in benign ovarian tumor tissues was higher than that in ovarian normal tissues （P 〈0.05）. The expression level of TM4SF1 gene in stage Ⅰ-Ⅱ ovarian tumor tissues （0. 124±0.02） was lower than that in stage Ⅲ（0. 164±0. 024）,（ P 〈0.05）. The expression level in the well-differentiated carcinoma tissues was lower than that in the middle-low carcinoma tissues, but there was no significantly different between the two cases （ P〉0.05）. Conclusion： The expression level of TM4SF1 mRNA may be associated with epithelial ovarian cancer.