中文摘要：

目的观察喘可治穴位注射治疗哮喘急性发作期寒哮肾阳亏虚型的临床疗效,并探讨其作用机制。方法将116例患者随机分为治疗组与对照组各58例,均予抗炎、化痰及解痉平喘等西医常规治疗,治疗组加用喘可治穴位注射。隔日1次,10 d为1个疗程。治疗前及治疗结束后对哮喘症状进行评分,测早晚1 s用力呼气容积（FEV1）,测定外周血细胞因子γ干扰素（TFN-γ）、白介素-4（IL-4）。结果两组治疗后哮喘症状评分和FEV1预计值与治疗前比较均得到了明显改善P〈0.05,且治疗组改善程度优于对照组P〈0.05;两组治疗后外周血IFN-γ含量明显上升,IL-4含量明显下降,与治疗前比较,差异有统计学意义（P〈0.05）,两组治疗后比较,差异也有统计学意义（P〈0.05）。结论喘可治穴位注射治疗哮喘急性发作期寒哮肾阳亏虚型的临床疗效确切,作用机制可能与通过纠正Th1/Th2细胞因子失衡,使免疫反应由Th2型向Th1型逆转有关。

英文摘要：

Objective To observe the effects of Chuankezhi acupoint injection in treatment ofacute attack of bronchial asthma with cold syndrome and deficiency of kidney-yang, and explore its action echanism. Methods 116 patients were randomly divided into treatment group and control group with 58 cases in each group. 2 groups were given anti-inflammatory, resolving phlegm and antispasmodic and conventional Western medicine treatment; treatment group was added with Chuankezhi acupoint injection treatment every other day, 10 days for a treatment course. Asth- ma symptom score, FEV1 IFN-γ and IL-4 of peripheral blood were tested in 2 groups before and after treatment. Results After treatment, asthma symptom score and FEV1 expected value were im- proved in 2 groups, and the data of treatment group was better than those of control group in im- proving degree. After treatment in 2 groups peripheral blood IFN-γ content increased obviously and IL-4 content decreased obviously; differences had statistical significances （P〈0.05）. Conclusion Chuankezhi acupoint injection in the treatment of acute attack of bronchial asthma with cold syn- drome and deficiency of kidney-yang is clinical effective, mechanism of action may be adjustingTh1/Th2 cytokine imbalance and reversing the immune response from Th2 to Th1.