基因治疗一直是肿瘤生物治疗的重要策略,而以溶瘤痘苗病毒为载体的肿瘤治疗近年来受到较多关注。该文总结了目前用于恶性肿瘤治疗的痘苗病毒和基于痘苗病毒载体的基因治疗研究进展及其在各个领域的成果。
Gene therapy has always been an important strategy for the biological treatment of tumor. Vaccinia virus has emerged as an attractive agent especially when used as an oncolytic virus vector. This review describes the use of vaccinia virus in cancer therapy as a oncolytic virus and the progress of vaccinia virus vector- based gene therapy and its achievements in various fields.