中文摘要：

Mrgs(Mas-related G protein-coupled receptors)是2001年发现的一类疼痛相关的新型G蛋白偶联受体(G protein-coupledreceptor,GPCR),其大部分成员mRNA特异地以非重叠形式表达于背根神经节(dorsal root ganglion,DRG)和三叉神经节(trigeminal ganglion,TG)的非肽能(nonpeptidergic)神经元,这种特异性表达模式提示该家族受体在生理学和药理学上有特殊意义.Mrgs的发现开启了研究伤害性感受器发育和功能的新领域,有助于对伤害性感受的理解及镇痛药物的研发.综述了Mrgs的分类、分布、表达调控以及在感觉回路和伤害性感受中的作用等方面的研究进展.

英文摘要：

A novel receptor family, the Mas-related G protein-coupled receptors (Mrgs, also called Sensory neuron-specific G protein-coupled receptors or SNSRs), was found in 2001. Interestingly, the mRNAs of Mrgs are expressed predominantly, if not exclusively, in non-overlapping subsets of nonpeptidergic neurons in dorsal root (DRG) and trigeminal ganglia (TG). This specific expression pattern implies significance in physiological and pharmaceutical sciences of pain processing. Study of Mrgs is a new field and will ...