中文摘要：

一氧化氮（NO）是神经元细胞内一种新型的神经递质,它由一氧化氮合酶（NOS）催化而成。在神经系统中神经元型一氧化氮合酶（nNOS）是NO合成的关键酶。大量研究表明,nNOS可调节多种生理和病理过程诸如炎性痛和神经病理性疼痛。该文通过介绍nNOS的结构、分布和影响nNOS活性的因素,阐述了nNOS在病理性疼痛中的重要作用,为此可通过调节nNOS表达来达到调节生理和病理过程。

英文摘要：

Nitric oxide （NO） acts as a new neurotransmitter in neuron cells. It is catalyzed by nitric oxide synthase （NOS）. Neuronal nitric oxide synthase（nNOS）is a key enzyme for NO production. Accumulating evidence shows that nNOS is involved in modulating physiological and pathological process such as imflammatory pain and neuropathic pain. This review concentrates on nNOS structural features, subcellular localization and factors regulating nNOS function, expounds the of importance of nNOS in pathological pain. So, we can modulate physiological and pathological process through regulating nNOS expression.