中文摘要：

就外周阿片受体的分布和阿片类物质的外周镇痛作用及机制的相关研究进展进行综述.阿片类物质的镇痛作用通过中枢和外周两种机制,研究表明：阿片类物质的外周镇痛作用是通过外周阿片受体起作用的.初级感觉神经元内及其外周末梢上存在着各类阿片受体,在炎症及神经损伤的情况下,阿片受体合成增加并转运到神经末梢或者受损部位,增加传导痛觉冲动的神经纤维中的阿片受体的表达,增强阿片类物质的外周镇痛作用.

英文摘要：

The distribution of peripheral opioid receptors and aralgesic effect and mechanisms of peripheral opioid ewre summarized.Analgesic effect of opioids includes central and peripheral mechanisms.Potent and significant analgesic effects can be brought about by opioids acting outside the central nervous system.Primary sensory neurons and their peripheral nerve terminals express opioid receptors.In inflammation and nerve injury cases,opioid receptors synthesis may increase and be transported to the peripheral nerve terminals and damaged parts.As a result,the expression of opioid receptors in nociceptive fibers may increase and make themselves more susceptible to opioid analgesics.